Dr. Hachulla has received consulting fees, speaking fees, and/or honoraria from Actelion, Pfizer, and GlaxoSmithKline (less than $10,000 each).
Systemic Sclerosis
The three-year incidence of pulmonary arterial hypertension associated with systemic sclerosis in a multicenter nationwide longitudinal study in France
Article first published online: 28 MAY 2009
DOI: 10.1002/art.24525
Copyright © 2009 by the American College of Rheumatology
Additional Information
How to Cite
Hachulla, E., de Groote, P., Gressin, V., Sibilia, J., Diot, E., Carpentier, P., Mouthon, L., Hatron, P.-Y., Jego, P., Allanore, Y., Tiev, K. P., Agard, C., Cosnes, A., Cirstea, D., Constans, J., Farge, D., Viallard, J.-F., Harle, J.-R., Patat, F., Imbert, B., Kahan, A., Cabane, J., Clerson, P., Guillevin, L. and Humbert, M. (2009), The three-year incidence of pulmonary arterial hypertension associated with systemic sclerosis in a multicenter nationwide longitudinal study in France. Arthritis & Rheumatism, 60: 1831–1839. doi: 10.1002/art.24525
Publication History
- Issue published online: 28 MAY 2009
- Article first published online: 28 MAY 2009
- Manuscript Accepted: 17 FEB 2009
- Manuscript Received: 5 AUG 2008
Funded by
- Actelion Pharmaceuticals France
REFERENCES
- 1, . Changes in causes of death in systemic sclerosis, 1972–2002. Ann Rheum Dis 2007; 66: 940–4.
- 2, , , , , , and the ItinérAIR-Sclérodermie Study Investigators. Risk factors for death and the 3-year survival of patients with systemic sclerosis: the French ItinérAIR-Sclérodermie study. Rheumatology (Oxford) 2009; 48: 304–8.
- 3, , , , , , et al. Early detection of pulmonary arterial hypertension in systemic sclerosis: a French nationwide prospective multicenter study. Arthritis Rheum 2005; 52: 3792–800.Direct Link:
- 4Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. Preliminary criteria for the classification of systemic sclerosis (scleroderma). Arthritis Rheum 1980; 23: 581–90.Direct Link:
- 5, , , , , , et al. Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol 1988; 15: 202–5.
- 6, . Recommendations on the management of pulmonary hypertension in clinical practice. Heart 2001; 86 Suppl 1: i1–13.
- 7The Criteria Committee of the New York Heart Association. Nomenclature and Criteria for Diagnosis of Diseases of the Heart and Great Vessels. 9th ed. Boston: Little, Brown; 1994. p. 253–6.
- 8, , , , , , et al. Diagnosis and differential assessment of pulmonary arterial hypertension. J Am Coll Cardiol 2004; 43 Suppl S: 40S–7S.
- 9, , , , , , et al. Clinical classification of pulmonary hypertension. J Am Coll Cardiol 2004; 43 Suppl S: 5S–12S.
- 10, , , , , , et al. Assessment of pulmonary arterial hypertension in patients with systemic sclerosis: comparison of noninvasive tests with results of right-heart catheterization. J Rheumatol 2008; 35: 458–65.
- 11, , , , , , et al. Natural history of pulmonary hypertension in a series of 131 patients with chronic obstructive lung disease. Am J Respir Crit Care Med 2001; 164: 219–24.
- 12, , , , , , et al. Skin thickness score in systemic sclerosis: an assessment of interobserver variability in 3 independent studies. J Rheumatol 1993; 20: 1892–6.
- 13, , , , , , et al. Prevalence and outcome in systemic sclerosis associated pulmonary arterial hypertension: application of a registry approach. Ann Rheum Dis 2003; 62: 1088–93.
- 14, , , , , , et al. Systemic sclerosis and its pulmonary complications in The Netherlands: an epidemiological study. Ann Rheum Dis 2008. E-pub ahead of print.
- 15, , , , , , et al. Pulmonary hypertension in systemic sclerosis: risk factors for progression and consequences for survival. Rheumatology (Oxford) 2001; 40: 453–9.
- 16, , , , , , et al. Post-menopause is the main risk factor for developing isolated pulmonary hypertension in systemic sclerosis. Ann N Y Acad Sci 2002; 966: 238–46.Direct Link:
- 17, , , , . Natural history of mild-moderate pulmonary hypertension and the risk factors for severe pulmonary hypertension in scleroderma. J Rheumatol 2006; 33: 269–74.
- 18, , , , , , et al. Systemic sclerosis: demographic, clinical, and serologic features and survival in 1,012 Italian patients. Medicine 2002; 81: 139–53.
- 19, , , , , , et al. Mortality and prognostic factors in Spanish patients with systemic sclerosis. Rheumatology (Oxford) 2003; 42: 71–5.
- 20, , , , , , et al. Evaluation of cardiac abnormalities by Doppler echocardiography in a large nationwide multicentric cohort of patients with systemic sclerosis. Ann Rheum Dis 2008; 67: 31–6.
- 21, , , , , , et al. Cardiac involvement in systemic sclerosis assessed by tissue-Doppler echocardiography during routine care: a controlled study of 100 consecutive patients. Arthritis Rheum 2008; 58: 1803–9.Direct Link:
- 22, , , , Isolated diffusing capacity reduction in systemic sclerosis. Arthritis Rheum 1992; 35: 765–70.Direct Link:
- 23, , , , , , et al. High N-terminal pro–brain natriuretic peptide levels and low diffusing capacity for carbon monoxide as independent predictors of the occurrence of precapillary pulmonary arterial hypertension in patients with systemic sclerosis. Arthritis Rheum 2008; 58: 284–91.Direct Link:
- 24, Predictors of isolated pulmonary hypertension in patients with systemic sclerosis and limited cutaneous involvement. Arthritis Rheum 2003; 48: 516–22.Direct Link:
- 25, , , , , , et al. Clinical risk assessment of organ manifestations in systemic sclerosis: a report from the EULAR Scleroderma Trials and Research group database. Ann Rheum Dis 2007; 66: 754–63.

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