Rheumatoid Arthritis
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Gene–environment interaction between the DRB1 shared epitope and smoking in the risk of anti–citrullinated protein antibody–positive rheumatoid arthritis: All alleles are important
Article first published online: 28 MAY 2009
DOI: 10.1002/art.24572
Copyright © 2009 by the American College of Rheumatology
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How to Cite
Lundström, E., Källberg, H., Alfredsson, L., Klareskog, L. and Padyukov, L. (2009), Gene–environment interaction between the DRB1 shared epitope and smoking in the risk of anti–citrullinated protein antibody–positive rheumatoid arthritis: All alleles are important. Arthritis & Rheumatism, 60: 1597–1603. doi: 10.1002/art.24572
Publication History
- Issue published online: 28 MAY 2009
- Article first published online: 28 MAY 2009
- Manuscript Accepted: 9 MAR 2009
- Manuscript Received: 3 JUN 2008
Funded by
- Swedish Research Council. Grant Number: 521-2006-5752
- Swedish Council for Working Life and Social Research
- NIH. Grant Numbers: P60-AR-47782, P60-AR-47782
- IMAGEN project. Grant Number: U19-AI-067152
- European Union Sixth Framework Programme (AutoCure project)
- Swedish Combine program
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- 2, , Immune-Regulatory Mechanisms in Systemic Autoimmune and Rheumatic Diseases, Clinical and Developmental Immunology, 2012, 2012, 1
- 3, , , Periodontitis, Porphyromonas, and the pathogenesis of rheumatoid arthritis, Mucosal Immunology, 2012, 5, 2, 112
- 4, , , , , , , , , , , , The balance of expression of PTPN22 splice forms is significantly different in rheumatoid arthritis patients compared with controls, Genome Medicine, 2012, 4, 1, 2
- 5, , , , A Systematic Review of Serum Biomarkers Anti-Cyclic Citrullinated Peptide and Rheumatoid Factor as Tests for Rheumatoid Arthritis, Autoimmune Diseases, 2011, 2011, 1
- 6, , , , , , , , Identification and functional characterization of T cells reactive to citrullinated vimentin in HLA–DRB1*0401–positive humanized mice and rheumatoid arthritis patients, Arthritis & Rheumatism, 2011, 63, 10Direct Link:
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- 8, , , , , , , , Smoking and two human leukocyte antigen genes interact to increase the risk for multiple sclerosis, Brain, 2011, 134, 3, 653
- 9, , , , , , , , , , , Smoking is associated with an increased risk of developing ACPA-positive but not ACPA-negative rheumatoid arthritis in Asian populations: evidence from the Malaysian MyEIRA caseâcontrol study, Modern Rheumatology, 2011,
- 10, , , A role for calreticulin in the pathogenesis of rheumatoid arthritis, Annals of the New York Academy of Sciences, 2010, 1209, 1Direct Link:
- 11, , , , , Genetic and environmental factors and the distribution of multiple sclerosis in Europe, European Journal of Neurology, 2010, 17, 9Direct Link:
- 12, , , , , Rheumatoid arthritis, Best Practice & Research Clinical Rheumatology, 2010, 24, 6, 733
- 13, , , , The impact of HLA-DRB alleles on the subclass titres of antibodies against citrullinated peptides, Rheumatology, 2010, 49, 10, 1862
- 14, The rheumatoid arthritis HLAâDRB1 shared epitope, Current Opinion in Rheumatology, 2010, 22, 3, 293
- 15, , Update on the genetic risk factors for rheumatoid arthritis, Expert Review of Clinical Immunology, 2010, 6, 1, 61
- 16, , Genetics: Every shared epitope allele for itself?, Nature Reviews Rheumatology, 2009, 5, 9, 477

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