Dr. Fernandez-Gutierrez has received speaking fees from Bristol-Myers Squibb (less than $10,000).
Rheumatoid Arthritis Clinical Studies
Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors
Article first published online: 27 AUG 2009
Copyright © 2009 by the American College of Rheumatology
Arthritis & Rheumatism
Volume 60, Issue 9, pages 2558–2564, September 2009
How to Cite
Suarez-Gestal, M., Calaza, M., Dieguez-Gonzalez, R., Perez-Pampin, E., Pablos, J. L., Navarro, F., Narvaez, J., Marenco, J. L., Herrero-Beaumont, G., Fernandez-Gutierrez, B., Lamas, J. R., de la Serna, A. R., Ortiz, A. M., Carreño, L., Cañete, J. D., Caliz, R., Blanco, F. J., Balsa, A., Gomez-Reino, J. J. and Gonzalez, A. (2009), Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors. Arthritis & Rheumatism, 60: 2558–2564. doi: 10.1002/art.24748
- Issue published online: 27 AUG 2009
- Article first published online: 27 AUG 2009
- Manuscript Accepted: 17 MAY 2009
- Manuscript Received: 9 MAR 2009
- Instituto de Salud Carlos III of the Spanish Health Ministry. Grant Numbers: PI06/0620, PI08/0744
- Xunta de Galicia. Grant Number: 07PXIB918091PR
- The Instituto de Salud Carlos III Research Network provided support for many of the collaborating research teams. Grant Number: RD08/0075
Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) share some genetic factors such as HLA, PTPN22, STAT4, and 6q23. The aim of this study was to determine whether 9 other SLE genetic factors are also implicated in RA susceptibility.
A characteristic single-nucleotide polymorphism (SNP) in each of 9 genetic factors, ITGAM (rs1143679), C8orf13–BLK (rs13277113), TYK2 (rs2304256), 1q25.1 (rs10798269), PXK (rs6445975), KIAA1542 (rs4963128), MECP2 (rs17435), BANK1 (rs17266594), and LY9 (rs509749), was studied in 1,635 patients with RA and 1,906 control subjects from Spain. The rs7574865 SNP in STAT4 was also included. Analyses were conducted globally and after stratification by sex and clinical features (anti–cyclic citrullinated peptide and rheumatoid factor, shared epitope, rheumatoid nodules, radiographic changes, sicca syndrome, and pneumonitis).
No association was observed between RA and any of the 9 newly identified SLE genetic factors. A meta-analysis using previous data was consistent with these results. In addition, there were no significant differences between individuals with and those without each of the clinical features analyzed, except the frequency of the minor allele in the C8orf13–BLK locus that was decreased in patients with sicca syndrome (14.6% versus 22.4% in controls; P = 0.003).
None of the 9 recently identified SLE risk factors showed association with RA. Therefore, common genetic factors affecting the pathogenesis of these 2 disorders seem to be limited, revealing that the genetic component contributes to the different expression of these diseases.