Dr. Eckstein has received consultant fees, speaking fees, and/or honoraria (less than $10,000 each) from Wyeth, Novo Nordisk, Synthes, and Novartis, and (more than $10,000 each) from Pfizer, Merck Serono, and Medtronic. Dr. Eckstein is CEO and co-owner of Chondrometrics, Ainring, Germany.
Magnetic resonance imaging-based cartilage loss in painful contralateral knees with and without radiographic joint space narrowing: Data from the osteoarthritis initiative
Article first published online: 27 AUG 2009
Copyright © 2009 by the American College of Rheumatology
Arthritis Care & Research
Volume 61, Issue 9, pages 1218–1225, 15 September 2009
How to Cite
Eckstein, F., Benichou, O., Wirth, W., Nelson, D. R., Maschek, S., Hudelmaier, M., Kwoh, C. K., Guermazi, A. and Hunter, D. (2009), Magnetic resonance imaging-based cartilage loss in painful contralateral knees with and without radiographic joint space narrowing: Data from the osteoarthritis initiative. Arthritis & Rheumatism, 61: 1218–1225. doi: 10.1002/art.24791
- Issue published online: 27 AUG 2009
- Article first published online: 27 AUG 2009
- Manuscript Accepted: 1 JUN 2009
- Manuscript Received: 26 JAN 2009
- Osteoarthritis Initiative. Grant Numbers: N01-AR-2-2258, N01-AR-2-2259, N01-AR-2-2260, N01-AR-2-2261, N01-AR-2-2262
- Eli Lilly, Indianapolis, Indiana
To determine by magnetic resonance imaging (MRI), whether knees with advanced radiographic disease (medial joint space narrowing [mJSN]) encounter greater longitudinal cartilage loss than contralateral knees with earlier disease (no or less mJSN).
Participants were selected from 2,678 cases in the Osteoarthritis Initiative, based on exhibition of bilateral pain, body mass index >25 (kg/m2), mJSN in 1 knee, no or less mJSN in the contralateral knee, and no lateral JSN in both knees. Eighty participants (mean ± SD age 60.6 ± 9.1 years) fulfilled these criteria. Medial tibial and femoral cartilage morphology was analyzed from the baseline and the 1-year followup MRI (sagittal double echo at steady state by 3.0T) of both knees by experienced readers blinded to the time point and mJSN status.
Knees with more radiographic mJSN displayed greater medial cartilage loss (−80 μm) assessed by MRI than contralateral knees with less mJSN (−57 μm). The difference reached statistical significance in participants with an mJSN grade of 2 or 3 (P = 0.005–0.08), but not in participants with an mJSN grade of 1 (P = 0.28–0.98). In knees with more mJSN, cartilage loss increased with higher grades of mJSN (P = 0.003 in the medial femur). Knees with an mJSN grade of 2 or 3 displayed greater cartilage loss in the weight-bearing medial femur than in the posterior femur or in the medial tibia (P = 0.048).
Knees with advanced mJSN displayed greater cartilage loss than contralateral knees with less mJSN. These data suggest that radiography can be used to stratify fast structural progressors, and that MRI cartilage thickness loss is more pronounced at advanced radiographic disease stage.