Dr. Guermazi has received consultant fees, speaking fees, and/or honoraria (less than $10,000) from Facet Solutions and (more than $10,000) from Merck Sorono, owns stock and/or holds stock options in Synarc, Inc., and is the President of Boston Imaging Core Lab, LLC.
Cartilage loss occurs in the same subregions as subchondral bone attrition: A within-knee subregion-matched approach from the multicenter osteoarthritis study
Article first published online: 29 OCT 2009
Copyright © 2009 by the American College of Rheumatology
Arthritis Care & Research
Volume 61, Issue 11, pages 1539–1544, 15 November 2009
How to Cite
Neogi, T., Felson, D., Niu, J., Lynch, J., Nevitt, M., Guermazi, A., Roemer, F., Lewis, C. E., Wallace, B. and Zhang, Y. (2009), Cartilage loss occurs in the same subregions as subchondral bone attrition: A within-knee subregion-matched approach from the multicenter osteoarthritis study. Arthritis & Rheumatism, 61: 1539–1544. doi: 10.1002/art.24824
- Issue published online: 29 OCT 2009
- Article first published online: 29 OCT 2009
- Manuscript Accepted: 30 JUN 2009
- Manuscript Received: 13 MAR 2009
- NIH. Grant Number: AR47785
- American College of Rheumatology Research and Education Foundation/Association of Specialty Professors Junior Career Development Award in Geriatrics (T. Franklin Williams Scholar Award)
- Arthritis Foundation Arthritis Investigator Award
- National Institute of Arthritis and Musculoskeletal and Skin Diseases. Grant Number: K23-AR055127
- NIH grant from the National Institute on Aging. Grant Numbers: U01-AG18820, U01-AG19069, U01-AG18947
By magnetic resonance imaging (MRI), subchondral bone attrition (SBA) can be seen in early osteoarthritis (OA), but the significance of this is unknown. We therefore evaluated whether SBA was associated with cartilage loss within the same subregion of the knee.
The Multicenter Osteoarthritis Study is a cohort of individuals who have or are at high risk for knee OA. At baseline and 30 months, participants' knee MRIs were graded using the Whole-Organ Magnetic Resonance Imaging Score in the 10 subregions of the tibiofemoral joint for cartilage morphology and SBA. We conducted analyses within a knee to eliminate between-person confounding, using an M:N (cases:controls) matched case–control approach with the 10 subregions of a person's knee forming a matched set. Cases within a knee were defined as subregions with cartilage loss, while controls were subregions in that same knee without cartilage loss. We evaluated the association of cartilage loss over 30 months with the presence of baseline SBA in the same subregion within that knee using conditional logistic regression.
SBA was associated with an odds ratio of 7.5 (95% confidence interval 5.6–9.9, P < 0.0001) for cartilage loss in the same subregion compared with subregions without any baseline SBA in our sample of 459 knees from participants, 64% of whom were women, with a mean age of 63 years and a mean body mass index of 30.5 kg/m2.
SBA is strongly associated with cartilage loss within the same subregion of a knee. SBA may directly influence overlying cartilage loss or serve as a marker of an area undergoing great compressive stress and in which cartilage loss is inevitable.