Spondylarthritis

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Association of ERAP1, but not IL23R, with ankylosing spondylitis in a Han Chinese population

  1. Stuart I. Davidson1,†,
  2. Xin Wu2,†,
  3. Yu Liu2,
  4. Meng Wei2,
  5. Patrick A. Danoy1,
  6. Gethin Thomas1,
  7. Qing Cai3,
  8. Linyun Sun4,
  9. Emma Duncan1,
  10. Niansong Wang5,
  11. Qinghong Yu6,
  12. Anlong Xu7,
  13. Yonggui Fu7,
  14. Matthew A. Brown1,‡,*,
  15. Huji Xu8,9,*

Article first published online: 29 OCT 2009

DOI: 10.1002/art.24933

Issue

Arthritis & Rheumatism

Arthritis & Rheumatism

Volume 60, Issue 11, pages 3263–3268, November 2009

Additional Information

How to Cite

Davidson, S. I., Wu, X., Liu, Y., Wei, M., Danoy, P. A., Thomas, G., Cai, Q., Sun, L., Duncan, E., Wang, N., Yu, Q., Xu, A., Fu, Y., Brown, M. A. and Xu, H. (2009), Association of ERAP1, but not IL23R, with ankylosing spondylitis in a Han Chinese population. Arthritis & Rheumatism, 60: 3263–3268. doi: 10.1002/art.24933

Author Information

  1. 1

    Princess Alexandra Hospital, University of Queensland, Brisbane, Queensland, Australia

  2. 2

    Changzheng Hospital, The Second Military Medical University, Shanghai, China

  3. 3

    Changhai Hospital, The Second Military Medical University, Shanghai, China

  4. 4

    Gulou Hospital, Nanjing, China

  5. 5

    No. 6 Hospital, Shanghai, China

  6. 6

    202 Hospital, Shenyang, China

  7. 7

    Sun Yat-Sen University, Guangzhou, China

  8. 8

    The Second Military Medical University, Shanghai, China

  9. 9

    Queensland Institute of Medical Research, Brisbane, Queensland, Australia

  1. †

    Mr. Davidson and Dr. Wu contributed equally to this work.

  2. ‡

    Dr. Brown has applied for patents relating to the diagnostic utility of IL23R and ERAP1 in AS.

*Diamantina Institute of Cancer, Immunology and Metabolic Medicine, University of Queensland, Brisbane, Queensland 4102, Australia

Publication History

  1. Issue published online: 29 OCT 2009
  2. Article first published online: 29 OCT 2009
  3. Manuscript Accepted: 2 AUG 2009
  4. Manuscript Received: 2 MAR 2009

Funded by

  • National Natural Science Foundation of China. Grant Number: 30972339
  • Science and Technology Commission of Shanghai Municipality. Grant Numbers: 07JC14070, 074017021
  • Australian National Health
  • Medical Research Council
  • Sun Yat-Sen University Science Foundation
  • Research Fund for the Doctoral Program of Higher Education of China

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REFERENCES

  • 1
    Zeng Q, Chen R, Darmawan J, Xiao Z, Chen S, Wigley R, et al. Rheumatic diseases in China. Arthritis Res Ther 2008; 10: R17.
  • 2
    Xiang YJ, Dai SM. Prevalence of rheumatic diseases and disability in China. Rheumatol Int 2009; 29: 481–90.
  • 3
    Brown M, Laval S, Brophy S, Calin A. Recurrence risk modelling of the genetic susceptibility to ankylosing spondylitis. Ann Rheum Dis 2000; 59: 883–6.
  • 4
    Brown MA. Non-major-histocompatibility-complex genetics of ankylosing spondylitis. Best Pract Res Clin Rheumatol 2006; 20: 611–21.
  • 5
    Wei JC, Tsai WC, Lin HS, Tsai CY, Chou CT. HLA-B60 and B61 are strongly associated with ankylosing spondylitis in HLA-B27-negative Taiwan Chinese patients. Rheumatology (Oxford) 2004; 43: 839–42.
  • 6
    Chou CT, Timms AE, Wei JC, Tsai WC, Wordsworth BP, Brown MA. Replication of association of IL1 gene complex members with ankylosing spondylitis in Taiwanese Chinese. Ann Rheum Dis 2006; 65: 1106–9.
  • 7
    Wellcome Trust Case Control Consortium, Australo-Anglo-American Spondylitis Consortium, Burton PR, Clayton DG, Cardon LR, Craddock N, et al. Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet 2007; 39: 1329–37.
  • 8
    Hammer GE, Gonzalez F, Champsaur M, Cado D, Shastri N. The aminopeptidase ERAAP shapes the peptide repertoire displayed by major histocompatibility complex class I molecules. Nat Immunol 2006; 7: 103–12.
  • 9
    Kanaseki T, Blanchard N, Hammer GE, Gonzalez F, Shastri N. ERAAP synergizes with MHC class I molecules to make the final cut in the antigenic peptide precursors in the endoplasmic reticulum. Immunity 2006; 25: 795–806.
  • 10
    Cui X, Rouhani FN, Hawari F, Levine SJ. Shedding of the type II IL-1 decoy receptor requires a multifunctional aminopeptidase, aminopeptidase regulator of TNF receptor type 1 shedding. J Immunol 2003; 171: 6814–9.
  • 11
    Cui X, Rouhani FN, Hawari F, Levine SJ. An aminopeptidase, ARTS-1, is required for interleukin-6 receptor shedding. J Biol Chem 2003; 278: 28677–85.
  • 12
    Cui X, Hawari F, Alsaaty S, Lawrence M, Combs C, Geng W, et al. Identification of ARTS-1 as a novel TNFR1-binding protein that promotes TNFR1 ectodomain shedding. J Clin Invest 2002; 110: 515–26.
  • 13
    Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM, et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005; 6: 1123–32.
  • 14
    Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 2005; 6: 1133–41.
  • 15
    Wilson NJ, Boniface K, Chan JR, McKenzie BS, Blumenschein WM, Mattson JD, et al. Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol 2007; 8: 950–7.
  • 16
    Manel N, Unutmaz D, Littman DR. The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt. Nat Immunol 2008; 9: 641–9.
  • 17
    Volpe E, Servant N, Zollinger R, Bogiatzi SI, Hupe P, Barillot E, et al. A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses. Nat Immunol 2008; 9: 650–7.
  • 18
    Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 2006; 314: 1461–3.
  • 19
    Tremelling M, Cummings F, Fisher SA, Mansfield J, Gwilliam R, Keniry A, et al. IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease. Gastroenterology 2007; 132: 1657–64.
  • 20
    Cargill M, Schrodi SJ, Chang M, Garcia VE, Brandon R, Callis KP, et al. A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet 2007; 80: 273–90.
  • 21
    Cua DJ, Sherlock J, Chen Y, Murphy CA, Joyce B, Seymour B, et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 2003; 421: 744–8.
  • 22
    Murphy CA, Langrish CL, Chen Y, Blumenschein W, McClanahan T, Kastelein RA, et al. Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med 2003; 198: 1951–7.
  • 23
    Jandus C, Bioley G, Rivals JP, Dudler J, Speiser D, Romero P. Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides. Arthritis Rheum 2008; 58: 2307–17.
    Direct Link:
  • 24
    Van der Linden S, Valkenburg HA, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis: a proposal for modification of the New York criteria. Arthritis Rheum 1984; 27: 361–8.
  • 25
    Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81: 559–75.
  • 26
    Chang SC, Momburg F, Bhutani N, Goldberg AL. The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by “molecular rule” mechanism. Proc Natl Acad Sci U S A 2005; 102: 17107–112.
  • 27
    Brown M, Pile K, Kennedy L, Calin A, Darke C, Bell J, et al. HLA class I associations of ankylosing spondylitis in the white population in the United Kingdom. Ann Rheum Dis 1996; 55: 268–70.
  • 28
    Liu Y, Jiang L, Cai Q, Danoy P, Barnardo M, Brown MA, et al. Predominant association of HLA-B2704 with ankylosing spondylitis in Chinese Han population from a large cohort case control association study. Tissue Antigens. In press.
  • 29
    Begovich AB, Carlton VE, Honigberg LA, Schrodi SJ, Chokkalingam AP, Alexander HC, et al. A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am J Hum Genet 2004; 75: 330–7.
  • 30
    Mori M, Yamada R, Kobayashi K, Kawaida R, Yamamoto K. Ethnic differences in allele frequency of autoimmune-disease-associated SNPs. J Hum Genet 2005; 50: 264–6.
  • 31
    Yamazaki K, Onouchi Y, Takazoe M, Kubo M, Nakamura Y, Hata A. Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients. J Hum Genet 2007; 52: 575–83.
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