Dr. Hayes receives royalties for the Manual for Physical Agents, 5th edition, Prentice Hall, 2000.
Osteoarthritis Clinical Studies
Article first published online: 8 MAR 2010
Copyright © 2010 by the American College of Rheumatology
Arthritis & Rheumatism
Volume 62, Issue 5, pages 1403–1411, May 2010
How to Cite
Chang, A., Hochberg, M., Song, J., Dunlop, D., Chmiel, J. S., Nevitt, M., Hayes, K., Eaton, C., Bathon, J., Jackson, R., Kwoh, C. K. and Sharma, L. (2010), Frequency of varus and valgus thrust and factors associated with thrust presence in persons with or at higher risk of developing knee osteoarthritis. Arthritis & Rheumatism, 62: 1403–1411. doi: 10.1002/art.27377
This article was prepared using an OAI public use data set in addition to data obtained within an NIH/NIAMS-funded ancillary grant.
This article does not necessarily reflect the opinions or views of the Osteoarthritis Initiative (OAI) Study Investigators, the NIH, or the private funding partners.
- Issue published online: 29 APR 2010
- Article first published online: 8 MAR 2010
- Accepted manuscript online: 8 MAR 2010 12:00AM EST
- Manuscript Accepted: 28 JAN 2010
- Manuscript Received: 19 AUG 2009
- NIH (National Institute of Arthritis and Musculoskeletal and Skin Diseases [NIAMS]). Grant Number: R01-AR-52918
- OAI. The OAI is a public–private partnership comprising five contracts funded by the NIH. Grant Numbers: N01-AR-2-2258, N01-AR-2-2259, N01-AR-2-2260, N01-AR-2-2261, N01-AR-2-2262
- OAI Study Investigators
- Merck Research Laboratories
- Novartis Pharmaceuticals Corporation
- Pfizer, Inc.
- Foundation for the NIH
Varus thrust observed during gait has been shown to be associated with a 4-fold increase in the risk of medial knee osteoarthritis (OA) progression. Valgus thrust is believed to be less common than varus thrust; the prevalence of each is uncertain. Racial differences in risk factors may help explain variations in the natural history of knee OA. We undertook this study to determine the frequency of varus and valgus thrust in African Americans and Caucasians and to identify factors associated with thrust presence.
The Osteoarthritis Initiative cohort includes men and women who have knee OA or are at increased risk of developing it. Trained examiners assessed thrust presence by gait observation. Logistic regression with generalized estimating equations was used to identify factors associated with thrust presence, and odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated.
Compared with Caucasians, African Americans had lower odds of varus thrust, controlling for age, sex, body mass index (BMI), injury, surgery, disease severity, strength, pain, and alignment in persons without knee OA (adjusted OR 0.50 [95% CI 0.36, 0.72]) and in those with knee OA (adjusted OR 0.46 [95% CI 0.34, 0.61]). Also independently associated with varus thrust were age, sex, BMI, disease severity, strength, and alignment. The odds of valgus thrust were greater for African Americans than for Caucasians in persons without knee OA (adjusted OR 1.69 [95% CI 1.02, 2.80]) and in those with knee OA (adjusted OR 1.98 [95% CI 1.35, 2.91]). Also independently associated with valgus thrust were disease severity and malalignment.
Compared with Caucasians, African Americans had lower odds of varus thrust and greater odds of valgus thrust. These findings may help explain the difference between these groups in the pattern of OA involvement at the knee.