Cartilage Biology
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Endothelial nitric oxide synthase deficiency in mice results in reduced chondrocyte proliferation and endochondral bone growth
Article first published online: 30 MAR 2010
DOI: 10.1002/art.27486
Copyright © 2010 by the American College of Rheumatology
Additional Information
How to Cite
Yan, Q., Feng, Q. and Beier, F. (2010), Endothelial nitric oxide synthase deficiency in mice results in reduced chondrocyte proliferation and endochondral bone growth. Arthritis & Rheumatism, 62: 2013–2022. doi: 10.1002/art.27486
Publication History
- Issue published online: 29 JUN 2010
- Article first published online: 30 MAR 2010
- Manuscript Accepted: 25 MAR 2010
- Manuscript Received: 18 DEC 2009
Funded by
- Canadian Institutes of Health Research. Grant Number: CIHR grant 3152A01
- Canada Research Chair in Musculoskeletal Health at the Schulich School of Medicine and Dentistry, University of Western Ontario
REFERENCES
- 1. Nitric oxide in inflammation and pain associated with osteoarthritis. Arthritis Res Ther 2008; 10 Suppl 2: S2.
- 2. Osteoarthritis and nitric oxide. Osteoarthritis Cartilage 2008; 16 Suppl 2: S15–20.
- 3, . Nitric oxide and bone. Immunology 2001; 103: 255–61.
- 4, , , . From molecules to mammals: what's NOS got to do with it? Acta Physiol Scand 2003; 179: 123–35.
- 5, , , . Global analyses of gene expression in early experimental osteoarthritis. Arthritis Rheum 2007; 56: 1854–68.
- 6
- 7
- 8, . Reaching a genetic and molecular understanding of skeletal development. Dev Cell 2002; 2: 389–406.
- 9, . The genetic basis for skeletal diseases. Nature 2003; 423: 343–8.
- 10, . Genetic control of skeletal development. Curr Opin Genet Dev 2001; 11: 527–32.
- 11. Genetic regulation of skeletal patterning, differentiation, and growth. Bone 1999; 25: 77–9.
- 12, , . The control of chondrogenesis. J Cell Biochem 2006; 97: 33–44.
- 13. Developmental regulation of the growth plate. Nature 2003; 423: 332–6.
- 14, , , , . Endochondral ossification: how cartilage is converted into bone in the developing skeleton. Int J Biochem Cell Biol 2008; 40: 46–62.
- 15, , . Molecular mechanisms regulating chondroblast differentiation. J Bone Joint Surg Am 2003; 85-A Suppl 2: 124–32.
- 16, , . MAP kinases in chondrocyte differentiation. Dev Biol 2003; 263: 165–75.
- 17, , . Bone development. Annu Rev Cell Dev Biol 2000; 16: 191–220.
- 18
- 19, , . Nitric oxide, C-type natriuretic peptide and cGMP as regulators of endochondral ossification. Dev Biol 2008; 319: 171–8.
- 20, , , , . Nitric oxide-nitric oxide synthase regulates key maturational events during chondrocyte terminal differentiation. Bone 2005; 37: 37–45.
- 21, , , , , , et al. Elevated blood pressures in mice lacking endothelial nitric oxide synthase. Proc Natl Acad Sci U S A 1996; 93: 13176–81.
- 22, , , . Perinatal development of endothelial nitric oxide synthase-deficient mice. Biol Reprod 2001; 64: 666–73.
- 23, , , , , . Genetic ablation of Rac1 in cartilage results in chondrodysplasia. Dev Biol 2007; 306: 612–23.
- 24, , , , , , et al. The role of Akt1 in terminal stages of endochondral bone formation: angiogenesis and ossification. Bone 2009; 45: 1133–45.
- 25, , , . Loss of ATRX in chondrocytes has minimal effects on skeletal development. PLoS One 2009; 4: e7106.
- 26, , , , . Microarray analyses of gene expression during chondrocyte differentiation identifies novel regulators of hypertrophy. Mol Biol Cell 2005; 16: 5316–33.
- 27, , , . p38 MAP kinase signaling is necessary for rat chondrosarcoma cell proliferation. Oncogene 2004; 23: 3726–31.
- 28, , , , , . RhoA/ROCK signaling suppresses hypertrophic chondrocyte differentiation. J Biol Chem 2004; 279: 13205–14.
- 29, , , , , , et al. C-type natriuretic peptide regulates endochondral bone growth through p38 MAP kinase-dependent and -independent pathways. BMC Dev Biol 2007; 7: 18.
- 30, , , . The PI3K pathway regulates endochondral bone growth through control of hypertrophic chondrocyte differentiation. BMC Dev Biol 2008; 8: 40.
- 31, , . RhoA/ROCK signaling regulates Sox9 expression and actin organization during chondrogenesis. J Biol Chem 2005; 280: 11626–34.
- 32. Cell-cycle control and the cartilage growth plate. J Cell Physiol 2005; 202: 1–8.
- 33, , , , , , et al. TGFβ and PTHrP control chondrocyte proliferation by activating cyclin D1 expression. Mol Biol Cell 2001; 12: 3852–63.
- 34, , , . The transcription factor ATF3 is upregulated during chondrocyte differentiation and represses cyclin D1 and A gene transcription. BMC Mol Biol 2006; 7: 30.
- 35, , , , . Control of chondrocyte gene expression by actin dynamics: a novel role of cholesterol/Rorα signaling in endochondral bone growth. J Cell Mol Med 2009; 13: 3497–516.
- 36, , . Effects of molecular oxygen on chick limb bud chondrogenesis. Differentiation 1988; 37: 14–9.
- 37, . Dynamic balancing of the dual nature of HIF-1α for cell survival. Cell Cycle 2004; 3: 853–4.
- 38, , , , , . Hypoxia in cartilage: HIF-1α is essential for chondrocyte growth arrest and survival. Genes Dev 2001; 15: 2865–76.
- 39, , , , , , et al. Dwarfism and early death in mice lacking C-type natriuretic peptide. Proc Natl Acad Sci U S A 2001; 98: 4016–21.
- 40, , , , , . Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II. Science 1996; 274: 2082–6.
- 41, , . Protein S-nitrosylation in health and disease: a current perspective. Trends Mol Med 2009; 15: 391–404.
- 42, , , , . Protein S-nitrosylation: purview and parameters. Nat Rev Mol Cell Biol 2005; 6: 150–66.
- 43, , , , . Identification of the cyclin D1 gene as a target of activating transcription factor 2 in chondrocytes. Proc Natl Acad Sci U S A 1999; 96: 1433–8.
- 44, , , , , , et al. Endothelial nitric oxide synthase gene-deficient mice demonstrate marked retardation in postnatal bone formation, reduced bone volume, and defects in osteoblast maturation and activity. Am J Pathol 2001; 158: 247–57.

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