Dr. Askling has received consulting fees, speaking fees, and/or honoraria from Wyeth and Bristol-Myers Squibb (less than $10,000 each).
Patients with early rheumatoid arthritis who smoke are less likely to respond to treatment with methotrexate and tumor necrosis factor inhibitors: Observations from the Epidemiological Investigation of Rheumatoid Arthritis and the Swedish Rheumatology Register cohorts
Version of Record online: 28 DEC 2010
Copyright © 2011 by the American College of Rheumatology
Arthritis & Rheumatism
Volume 63, Issue 1, pages 26–36, January 2011
How to Cite
Saevarsdottir, S., Wedrén, S., Seddighzadeh, M., Bengtsson, C., Wesley, A., Lindblad, S., Askling, J., Alfredsson, L. and Klareskog, L. (2011), Patients with early rheumatoid arthritis who smoke are less likely to respond to treatment with methotrexate and tumor necrosis factor inhibitors: Observations from the Epidemiological Investigation of Rheumatoid Arthritis and the Swedish Rheumatology Register cohorts. Arthritis & Rheumatism, 63: 26–36. doi: 10.1002/art.27758
- Issue online: 28 DEC 2010
- Version of Record online: 28 DEC 2010
- Accepted manuscript online: 22 SEP 2010 09:15AM EST
- Manuscript Accepted: 14 SEP 2010
- Manuscript Received: 16 APR 2010
- Epidemiological Investigation of Rheumatoid Arthritis study was supported by grants from the Swedish Medical Research Council
- Stockholm County Council
- Flight Attendant Medical Research Institute
- Swedish Council for Working Life and Social Research
- King Gustaf V's 80-Year Foundation
- Swedish Rheumatism Association
- Swedish Combine project
- European Community Sixth Framework Programme (project AutoCure)
- 2Progression of joint damage in early rheumatoid arthritis: association with HLA–DRB1, rheumatoid factor, and anti–citrullinated protein antibodies in relation to different treatment strategies. Arthritis Rheum 2008; 58: 1293–8., , , , , , et al.
- 21Development and validation of the European League Against Rheumatism response criteria for rheumatoid arthritis: comparison with the preliminary American College of Rheumatology and the World Health Organization/International League Against Rheumatism criteria. Arthritis Rheum 1996; 39: 34–40., , , , , .
- 23Epidemiological Investigation of Rheumatoid Arthritis Study Group. A gene–environment interaction between smoking and shared epitope genes in HLA–DR provides a high risk of seropositive rheumatoid arthritis. Arthritis Rheum 2004; 50: 3085–92., , , , , for the
- 24Epidemiological Investigation of Rheumatoid Arthritis Study Group. A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA–DR (shared epitope)–restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum 2006; 54: 38–46., , , , , , et al, and the
- 32Association of rheumatoid factor and anti-cyclic citrullinated peptide positivity, but not carriage of shared epitope or PTPN22 susceptibility variants, with anti-tumour necrosis factor response in rheumatoid arthritis. Ann Rheum Dis 2009; 68: 69–74., , , , , , et al.