The findings and conclusions reported herein are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.
Differences in multijoint radiographic osteoarthritis phenotypes among African Americans and Caucasians: The Johnston County Osteoarthritis Project†
Article first published online: 29 NOV 2011
Copyright © 2011 by the American College of Rheumatology
Arthritis & Rheumatism
Volume 63, Issue 12, pages 3843–3852, December 2011
How to Cite
Nelson, A. E., Renner, J. B., Schwartz, T. A., Kraus, V. B., Helmick, C. G. and Jordan, J. M. (2011), Differences in multijoint radiographic osteoarthritis phenotypes among African Americans and Caucasians: The Johnston County Osteoarthritis Project. Arthritis & Rheumatism, 63: 3843–3852. doi: 10.1002/art.30610
- Issue published online: 29 NOV 2011
- Article first published online: 29 NOV 2011
- Accepted manuscript online: 20 OCT 2011 03:51PM EST
- Manuscript Accepted: 9 AUG 2011
- Manuscript Received: 26 APR 2011
- NIH (National Institute of Arthritis and Musculoskeletal and Skin Diseases). Grant Number: P60-AR-30701
- Centers for Disease Control and Prevention and the Association of Schools of Public Health (CDC/ASPH). Grant Numbers: S043, S3486
- American College of Rheumatology Research and Education Foundation (Clinical Investigator Fellowship award 2009)
- NIH (National Institute of Arthritis and Musculoskeletal and Skin Diseases Loan Repayment award. Grant Number: L30-AR-056604
To define and contrast multiple joint radiographic osteoarthritis (OA) phenotypes describing hand and whole-body radiographic OA among African Americans and Caucasians.
We conducted a cross-sectional analysis in the Johnston County Osteoarthritis Project, using radiographic data for the hands, tibiofemoral (TF) joints, patellofemoral joints, hips, and lumbosacral (LS) spine. Radiographs were read for OA by a single radiologist using standard atlases. Fisher's exact test, with correction for multiple comparisons, was used to compare phenotype frequencies by race and sex. Logistic regression was used to provide odds ratios, which were adjusted for sex, age, and body mass index (BMI).
Sixteen mutually exclusive hand (n = 2,083) and 32 whole-body (n = 1,419) radiographic OA phenotypes were identified. We found that in comparison to Caucasians, African Americans had significantly less frequent radiographic OA of the distal interphalangeal joints, both in isolation and in combination with other hand joint sites, but had comparable frequencies of radiographic OA for other hand joint sites. Moreover, African Americans had less frequent radiographic OA of the hand, both in isolation and in combination with other joint sites, as compared to Caucasians. In contrast, African Americans had more than twice the odds of isolated OA of the TF joint and 77% higher odds of radiographic OA of the TF joint and LS spine together as compared to Caucasians.
Even after adjustment for sex, age, and BMI, African Americans were less likely than Caucasians to have hand radiographic OA phenotypes, but more likely to have knee radiographic OA phenotypes involving the TF joint. African Americans may have a higher burden of multiple large-joint OA involvement not captured by most definitions of “generalized OA.”