Patents for the Knee Osteoarthritis Computer-Aided Diagnosis (KOACAD) system are held by the University of Tokyo.
Independent association of joint space narrowing and osteophyte formation at the knee with health-related quality of life in Japan: A cross-sectional study†
Article first published online: 29 NOV 2011
Copyright © 2011 by the American College of Rheumatology
Arthritis & Rheumatism
Volume 63, Issue 12, pages 3859–3864, December 2011
How to Cite
Muraki, S., Oka, H., Akune, T., En-Yo, Y., Yoshida, M., Suzuki, T., Yoshida, H., Ishibashi, H., Tokimura, F., Yamamoto, S., Nakamura, K., Kawaguchi, H. and Yoshimura, N. (2011), Independent association of joint space narrowing and osteophyte formation at the knee with health-related quality of life in Japan: A cross-sectional study. Arthritis & Rheumatism, 63: 3859–3864. doi: 10.1002/art.30641
- Issue published online: 29 NOV 2011
- Article first published online: 29 NOV 2011
- Accepted manuscript online: 26 AUG 2011 01:20PM EST
- Manuscript Accepted: 18 AUG 2011
- Manuscript Received: 24 AUG 2010
- Japanese Ministry of Education, Culture, Sports, Science, and Technology. Grant Numbers: Grants-in-Aid S19109007, B20390182, C20591737, C20591774 for Scientific Research, A18689031 for Young Scientists, 19659305 for Exploratory Research
- Japanese Ministry of Health, Labor, and Welfare. Grant Numbers: H17-Men-eki-009, H18-Choujyu-037, H20-Choujyu-009, H21-Chouju-Wakate-011
- Japanese Orthopaedic Association
- JOA-Subsidized Science Project Research 2006-1
- Japan Orthopaedics and Traumatology Foundation. Grant Number: 166
To clarify the individual associations of joint space narrowing (JSN) and osteophytosis at the knee with quality of life (QOL) in Japanese men and women using a large-scale population-based cohort from the Research on Osteoarthritis Against Disability (ROAD) study.
The associations of minimum joint space width (JSW) and osteophyte area in the medial compartment of the knee with QOL parameters, such as the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), were examined. Minimum JSW and osteophyte area in the medial compartment of the knee were measured using a computer-aided system for the diagnosis of knee osteoarthritis.
Of the 3,040 participants in the ROAD study, the present study included 2,039 participants age 40 years or older who completed the questionnaires (741 men and 1,298 women with a mean ± SD age of 68.6 ± 10.9 years). Multiple regression analysis after adjustment for age and body mass index showed that minimum JSW was significantly associated with scores on the pain domains of the WOMAC in men and women, while osteophyte area was significantly associated with scores on the physical function domains of the WOMAC in men and women.
The findings of this cross-sectional study using a large-scale population from the ROAD study indicate that JSN and osteophytosis are independently associated with QOL.