Sleep problems and risk of fibromyalgia: Longitudinal data on an adult female population in Norway
Article first published online: 29 DEC 2011
Copyright © 2012 by the American College of Rheumatology
Arthritis & Rheumatism
Volume 64, Issue 1, pages 281–284, January 2012
How to Cite
Mork, P. J. and Nilsen, T. I. L. (2012), Sleep problems and risk of fibromyalgia: Longitudinal data on an adult female population in Norway. Arthritis & Rheumatism, 64: 281–284. doi: 10.1002/art.33346
- Issue published online: 29 DEC 2011
- Article first published online: 29 DEC 2011
- Accepted manuscript online: 11 NOV 2011 12:34PM EST
- Manuscript Accepted: 8 SEP 2011
- Manuscript Received: 19 JAN 2011
- HUNT Research Centre at the Norwegian University of Science and Technology
- Nord-Trøndelag County Council
- Norwegian Institute of Public Health
Sleep problems are common among patients with fibromyalgia (FM). However, it is not known whether poor sleep is a contributing factor in FM or a consequence of the illness. The aim of the current study was to prospectively investigate the association between self-reported sleep problems and risk of FM among adult women.
We longitudinally studied 12,350 women who did not have FM, musculoskeletal pain, or physical impairments at baseline (1984–1986). A generalized linear model was used to calculate the adjusted relative risk (RR) of FM at followup in 1995–1997.
Incident FM was reported by 327 women at followup. A dose-dependent association was found between sleep problems and risk of FM (P for trend < 0.001), with an adjusted RR of 3.43 (95% confidence interval [95% CI] 2.26–5.19) among women who reported having sleep problems often or always, compared to women who never experienced sleep problems. Age-stratified analysis showed that women age ≥45 years who reported having sleep problems often or always had an adjusted RR of 5.41 (95% CI 2.65–11.05), whereas the corresponding RR for women ages 20–44 years who reported having sleep problems often or always was 2.98 (95% CI 1.76–5.05).
These prospective data indicate a strong dose-dependent association between sleep problems and risk of FM. The association is somewhat, although not significantly, stronger in middle-aged and older women than in younger women.