• 1
    Alger BE, Kim J. Supply and demand for endocannabinoids. Trends Neurosci 2011; 34: 30415.
  • 2
    Tanasescu R, Constantinescu CS. Cannabinoids and the immune system: an overview. Immunobiology 2010; 215: 58897.
  • 3
    Grimaldi C, Pisanti S, Laezza C, Malfitano AM, Santoro A, Vitale M, et al. Anandamide inhibits adhesion and migration of breast cancer cells. Exp Cell Res 2006; 312: 36373.
  • 4
    Cencioni MT, Chiurchiu V, Catanzaro G, Borsellino G, Bernardi G, Battistini L, et al. Anandamide suppresses proliferation and cytokine release from primary human T-lymphocytes mainly via CB2 receptors. PLoS One 2010; 5: e8688.
  • 5
    Kuc C, Jenkins A, Van Dross RT. Arachidonoyl ethanolamide (AEA)-induced apoptosis is mediated by J-series prostaglandins and is enhanced by fatty acid amide hydrolase (FAAH) blockade. Mol Carcinog 2012; 51: 13949.
  • 6
    Athanasiou A, Clarke AB, Turner AE, Kumaran NM, Vakilpour S, Smith PA, et al. Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death. Biochem Biophys Res Commun 2007; 364: 1317.
  • 7
    Placzek EA, Okamoto Y, Ueda N, Barker EL. Mechanisms for recycling and biosynthesis of endogenous cannabinoids anandamide and 2-arachidonylglycerol. J Neurochem 2008; 107: 9871000.
  • 8
    Duggan KC, Hermanson DJ, Musee J, Prusakiewicz JJ, Scheib JL, Carter BD, et al. (R)-profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2. Nat Chem Biol 2011; 7: 8039.
  • 9
    Glaser ST, Kaczocha M. Cyclooxygenase-2 mediates anandamide metabolism in the mouse brain. J Pharmacol Exp Ther 2010; 335: 3808.
  • 10
    Patsos HA, Greenhough A, Hicks DJ, Al KM, Collard TJ, Lane JD, et al. The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells. Int J Oncol 2010; 37: 18793.
  • 11
    Richardson D, Pearson RG, Kurian N, Latif ML, Garle MJ, Barrett DA, et al. Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis. Arthritis Res Ther 2008; 10: R43.
  • 12
    Kinsey SG, Naidu PS, Cravatt BF, Dudley DT, Lichtman AH. Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice. Pharmacol Biochem Behav 2011; 99: 71825.
  • 13
    McPartland JM. Expression of the endocannabinoid system in fibroblasts and myofascial tissues. J Bodyw Mov Ther 2008; 12: 16982.
  • 14
    Engler A, Aeschlimann A, Simmen BR, Michel BA, Gay RE, Gay S, et al. Expression of transient receptor potential vanilloid 1 (TRPV1) in synovial fibroblasts from patients with osteoarthritis and rheumatoid arthritis. Biochem Biophys Res Commun 2007; 359: 8848.
  • 15
    Toth A, Blumberg PM, Boczan J. Anandamide and the vanilloid receptor (TRPV1). Vitam Horm 2009; 81: 389419.
  • 16
    Brailoiu GC, Oprea TI, Zhao P, Abood ME, Brailoiu E. Intracellular cannabinoid type 1 (CB1) receptors are activated by anandamide. J Biol Chem 2011; 286: 2916674.
  • 17
    Di S, Malcher-Lopes R, Halmos KC, Tasker JG. Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus: a fast feedback mechanism. J Neurosci 2003; 23: 48507.
  • 18
    Tasker J. Endogenous cannabinoids take the edge off neuroendocrine responses to stress. Endocrinology 2004; 145: 542930.
  • 19
    Zoppi S, Perez Nievas BG, Madrigal JL, Manzanares J, Leza JC, Garcia-Bueno B. Regulatory role of cannabinoid receptor 1 in stress-induced excitotoxicity and neuroinflammation. Neuropsychopharmacology 2011; 36: 80518.
  • 20
    Lowin T, Straub RH, Neumann E, Bosserhoff A, Vogel C, Moissl C, et al. Glucocorticoids increase α5 integrin expression and adhesion of synovial fibroblasts but inhibit ERK signaling, migration, and cartilage invasion. Arthritis Rheum 2009; 60: 362332.
  • 21
    Vicente-Manzanares M, Horwitz AR. Cell migration: an overview. Methods Mol Biol 2011; 769: 124.
  • 22
    Lowin T, Straub RH. Integrins and their ligands in rheumatoid arthritis. Arthritis Res Ther 2011; 13: 244.
  • 23
    Alon R, Shulman Z. Chemokine triggered integrin activation and actin remodeling events guiding lymphocyte migration across vascular barriers. Exp Cell Res 2011; 317: 63241.
  • 24
    Schedel J, Wenglen C, Distler O, Muller-Ladner U, Scholmerich J, Heinegard D, et al. Differential adherence of osteoarthritis and rheumatoid arthritis synovial fibroblasts to cartilage and bone matrix proteins and its implication for osteoarthritis pathogenesis. Scand J Immunol 2004; 60: 51423.
  • 25
    Tanaka Y. Integrin activation by chemokines: relevance to inflammatory adhesion cascade during T cell migration. Histol Histopathol 2000; 15: 116976.
  • 26
    Laudanna C, Kim JY, Constantin G, Butcher E. Rapid leukocyte integrin activation by chemokines. Immunol Rev 2002; 186: 3746.
  • 27
    Pereira JP, An J, Xu Y, Huang Y, Cyster JG. Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids. Nat Immunol 2009; 10: 40311.
  • 28
    Rossi B, Zenaro E, Angiari S, Ottoboni L, Bach S, Piccio L, et al. Inverse agonism of cannabinoid CB1 receptor blocks the adhesion of encephalitogenic T cells in inflamed brain venules by a protein kinase A-dependent mechanism. J Neuroimmunol 2011; 233: 97105.
  • 29
    Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 31524.
  • 30
    Miller LE, Justen HP, Scholmerich J, Straub RH. The loss of sympathetic nerve fibers in the synovial tissue of patients with rheumatoid arthritis is accompanied by increased norepinephrine release from synovial macrophages. FASEB J 2000; 14: 2097107.
  • 31
    Kingsley PJ, Marnett LJ. Analysis of endocannabinoids, their congeners and COX-2 metabolites. J Chromatogr B Analyt Technol Biomed Life Sci 2009; 877: 274654.
  • 32
    Kinbara K, Goldfinger LE, Hansen M, Chou FL, Ginsberg MH. Ras GTPases: integrins' friends or foes? Nat Rev Mol Cell Biol 2003; 4: 76776.
  • 33
    Hyduk SJ, Rullo J, Cano AP, Xiao H, Chen M, Moser M, et al. Talin-1 and kindlin-3 regulate α4β1 integrin-mediated adhesion stabilization, but not G protein-coupled receptor-induced affinity upregulation. J Immunol 2011; 187: 43608.
  • 34
    Shattil SJ, Kim C, Ginsberg MH. The final steps of integrin activation: the end game. Nat Rev Mol Cell Biol 2010; 11: 288300.
  • 35
    Tran H, Pankov R, Tran SD, Hampton B, Burgess WH, Yamada KM. Integrin clustering induces kinectin accumulation. J Cell Sci 2002; 115: 203140.
  • 36
    Villagomez M, Szabo E, Podcheko A, Feng T, Papp S, Opas M. Calreticulin and focal-contact-dependent adhesion. Biochem Cell Biol 2009; 87: 54556.
  • 37
    Hyduk SJ, Chan JR, Duffy ST, Chen M, Peterson MD, Waddell TK, et al. Phospholipase C, calcium, and calmodulin are critical for α4β1 integrin affinity up-regulation and monocyte arrest triggered by chemoattractants. Blood 2007; 109: 17684.
  • 38
    Currie S, Rainbow RD, Ewart MA, Kitson S, Pliego EH, Kane KA, et al. IP3R-mediated Ca2+ release is modulated by anandamide in isolated cardiac nuclei. J Mol Cell Cardiol 2008; 45: 80411.
  • 39
    Van der Stelt M, Trevisani M, Vellani V, De Petrocellis L, Schiano Moriello A, Campi B, et al. Anandamide acts as an intracellular messenger amplifying Ca2+ influx via TRPV1 channels [published erratum appears in EMBO J 2005;24:3517–8]. EMBO J 2005; 24: 302637.
  • 40
    Shi WL, Ma Q, Zhang LD, Huang JL, Zhou J, Liu L, et al. Corticosterone rapidly promotes respiratory burst of mouse peritoneal macrophages via non-genomic mechanism. Chin Med J (Engl) 2011; 124: 312732.
  • 41
    Ross RA. Anandamide and vanilloid TRPV1 receptors. Br J Pharmacol 2003; 140: 790801.
  • 42
    Maccarrone M, Dainese E, Oddi S. Intracellular trafficking of anandamide: new concepts for signaling. Trends Biochem Sci 2010; 35: 6018.
  • 43
    Tsubouchi Y, Kawahito Y, Kohno M, Inoue K, Hla T, Sano H. Feedback control of the arachidonate cascade in rheumatoid synoviocytes by 15-deoxy-Δ12,14-prostaglandin J2. Biochem Biophys Res Commun 2001; 283: 7505.
  • 44
    Kalajdzic T, Faour WH, He QW, Fahmi H, Martel-Pelletier J, Pelletier JP, et al. Nimesulide, a preferential cyclooxygenase 2 inhibitor, suppresses peroxisome proliferator–activated receptor induction of cyclooxygenase 2 gene expression in human synovial fibroblasts: evidence for receptor antagonism. Arthritis Rheum 2002; 46: 494506.
  • 45
    McHugh D, Page J, Dunn E, Bradshaw HB. Δ9-Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells. Br J Pharmacol 201; 165: 241424.
  • 46
    Bradshaw HB, Rimmerman N, Hu SS, Benton VM, Stuart JM, Masuda K, et al. The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonoyl glycine by two distinct pathways. BMC Biochem 2009; 10: 14.
  • 47
    Waldeck-Weiermair M, Zoratti C, Osibow K, Balenga N, Goessnitzer E, Waldhoer M, et al. Integrin clustering enables anandamide-induced Ca2+ signaling in endothelial cells via GPR55 by protection against CB1-receptor-triggered repression. J Cell Sci 2008; 121: 170417.
  • 48
    Crofford LJ. COX-2 in synovial tissues. Osteoarthritis Cartilage 1999; 7: 4068.
  • 49
    Telleria-Diaz A, Schmidt M, Kreusch S, Neubert AK, Schache F, Vazquez E, et al. Spinal antinociceptive effects of cyclooxygenase inhibition during inflammation: involvement of prostaglandins and endocannabinoids. Pain 2010; 148: 2635.