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ART_37761_sm_SupplFigure1.tif2049KSupplementary Figure 1. Graph theoretical analysis. A and B, Connectivity networks related to pain (compression paradigm) in patients with rheumatoid arthritis (RA) that responded to tumor necrosis factor inhibitors (TNFi) (A) and patients with RA that did not respond to TNFi (B) before (t0) and 3 days after treatment with certolizumab. Nodes represent brain structures, and edges represent the connectivity based on blood oxygen level---dependent time course correlation between brain structures. The size of the node indicates the node's degree; isolated nodes (with a degree of 0) were removed. Node positions indicate the anatomic centroids of the brain structures derived from a horizontal projection. Node colors represent different functional groups of brain structures. The thickness of each vertex indicates the connection strength (i.e., the correlation value). Arrows indicate brain structures that showed consistent differences in connectivity between responders and nonresponders. (Green arrows indicate the thalamus; red arrows indicate the posterior cingulate cortex; blue arrows indicate the insular cortex; gray arrows indicate the periaqueductal gray matter.) C, Brain structures analyzed for connectivity networks. CONTRA = contralateral; IPSI = ipsilateral; MPFC = medial prefrontal cortex; LPFC = lateral prefrontal cortex; AINS = anterior insular cortex; PINS = posterior insular cortex; MOT = motor cortex; ACC = anterior cingulate cortex; PCC = posterior cingulate cortex; S1 = primary somatosensory cortex; S2 = secondary somatosensory cortex; TH = thalamus; PAR = parietal cortex; PAG = periaqueductal gray matter; CB = cerebellum.

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