The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the CDC or the NIH.
Brief Report: Differences in multijoint symptomatic osteoarthritis phenotypes by race and sex: The Johnston County Osteoarthritis Project†
Article first published online: 28 JAN 2013
Copyright © 2013 by the American College of Rheumatology
Arthritis & Rheumatism
Volume 65, Issue 2, pages 373–377, February 2013
How to Cite
Nelson, A. E., Golightly, Y. M., Renner, J. B., Schwartz, T. A., Kraus, V. B., Helmick, C. G. and Jordan, J. M. (2013), Brief Report: Differences in multijoint symptomatic osteoarthritis phenotypes by race and sex: The Johnston County Osteoarthritis Project. Arthritis & Rheumatism, 65: 373–377. doi: 10.1002/art.37775
- Issue published online: 28 JAN 2013
- Article first published online: 28 JAN 2013
- Manuscript Accepted: 23 OCT 2012
- Manuscript Received: 23 JUL 2012
- 2009 Clinical Investigator Fellowship Award from the Rheumatology Research Foundation of the American College of Rheumatology
- NIH (National Institute of Arthritis and Musculoskeletal and Skin Diseases). Grant Numbers: K23-AR-061406, P60-AR-30701, P01-AR-050245
- Arthritis Foundation Postdoctoral Fellowship Award
- CDC/Association of Schools of Public Health. Grant Numbers: S043, S3486
- NIH (Claude D. Pepper grant from the National Institute on Aging). Grant Number: 5-P30-AG028716
To determine differences in the phenotypes (patterns) of multiple-joint symptomatic osteoarthritis (OA) involvement by race and sex.
A cross-sectional analysis of symptomatic OA phenotypes was performed in a community-based cohort, comprising subjects for whom data were collected from 4 sites of symptomatic OA involvement (the hands, knees, hips, and lumbosacral [LS] spine) at a single visit (2003–2010). Mutually exclusive phenotypes describing all combinations of these 4 sites were compared by race and by sex, using Fisher's exact tests. For those phenotypes occurring in >40 subjects, logistic regression was performed, with adjustments for race, sex, age, and body mass index (BMI), and interactions of race and sex were assessed.
The sample included 1,650 participants, of whom 36% were men and 32% were African American. The mean age of the subjects was 66 years, and the mean BMI was 31 kg/m2. Overall, in this sample, 13% of subjects had symptomatic hand OA, 25% had symptomatic knee OA, 11% had symptomatic hip OA, and 28% had symptomatic LS spine OA. African Americans, as compared with Caucasians, were less likely to have involvement of symptomatic OA in the hand only, or in some combination of the hand and other sites, but were more likely to have involvement of the knee only. Men, as compared to women, were less likely to have involvement of the hand only, but were more likely to have involvement of the LS spine only.
There are differences in the phenotypes of multiple-joint symptomatic OA involvement by race and by sex that may influence the definitions of multiple-joint, or generalized, OA.