Drs. Arnold and Fan contributed equally to this work.
The Fibromyalgia Family Study: A Genome-Wide Linkage Scan Study
Version of Record online: 28 MAR 2013
Copyright © 2013 by the American College of Rheumatology
Arthritis & Rheumatism
Volume 65, Issue 4, pages 1122–1128, April 2013
How to Cite
Arnold, L. M., Fan, J., Russell, I. J., Yunus, M. B., Khan, M. A., Kushner, I., Olson, J. M. and Iyengar, S. K. (2013), The Fibromyalgia Family Study: A Genome-Wide Linkage Scan Study. Arthritis & Rheumatism, 65: 1122–1128. doi: 10.1002/art.37842
- Issue online: 28 MAR 2013
- Version of Record online: 28 MAR 2013
- Accepted manuscript online: 28 DEC 2012 11:29AM EST
- Manuscript Accepted: 18 DEC 2012
- Manuscript Received: 31 JUL 2012
- NIH (National Institute of Arthritis and Musculoskeletal and Skin Diseases). Grant Number: N01-AR-9-2235
- NIH (National Center for Research Resources, Clinical and Translational Science Award program). Grant Number: KL2-RR-024990
- NIH (National Center for Research Resources, US Public Health Service resource). Grant Number: RR-03655
Familial aggregation of fibromyalgia has been increasingly recognized. The goal of this study was to conduct a genome-wide linkage scan to identify susceptibility loci for fibromyalgia.
We genotyped members of 116 families from the Fibromyalgia Family Study and performed a model-free genome-wide linkage analysis of fibromyalgia with 341 microsatellite markers, using the Haseman-Elston regression approach.
The estimated sibling recurrence risk ratio (λs) for fibromyalgia was 13.6 (95% confidence interval 10.0–18.5), based on a reported population prevalence of 2%. Genome-wide suggestive evidence of linkage was observed at markers D17S2196 (empirical P [Pe] = 0.00030) and D17S1294 (Pe = 0.00035) on chromosome 17p11.2–q11.2.
The estimated sibling recurrence risk ratio (λs) observed in this study suggests a strong genetic component of fibromyalgia. This is the first report of genome-wide suggestive linkage of fibromyalgia to the chromosome 17p11.2–q11.2 region. Further investigation of these multicase families from the Fibromyalgia Family Study is warranted to identify potential causal risk variants for fibromyalgia.