Dr. Parrish has received consulting fees, speaking fees, and/or honoraria from Siemens Medical Systems, Australia (less than $10,000).
Brain Morphometric Changes Associated With Childhood-Onset Systemic Lupus Erythematosus and Neurocognitive Deficit
Version of Record online: 26 JUL 2013
© 2013 The Authors. Arthritis & Rheumatism is published by Wiley Periodicals, Inc. on behalf of the American College of Rheumatology.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Arthritis & Rheumatism
Volume 65, Issue 8, pages 2190–2200, August 2013
How to Cite
Gitelman, D. R., Klein-Gitelman, M. S., Ying, J., Sagcal-Gironella, A. C. P., Zelko, F., Beebe, D. W., DiFrancesco, M., Parrish, T., Hummel, J., Beckwith, T. and Brunner, H. I. (2013), Brain Morphometric Changes Associated With Childhood-Onset Systemic Lupus Erythematosus and Neurocognitive Deficit. Arthritis & Rheumatism, 65: 2190–2200. doi: 10.1002/art.38009
The contents herein are solely the responsibility of the authors and do not necessarily represent the official views of the National Institutes of Health.
- Issue online: 26 JUL 2013
- Version of Record online: 26 JUL 2013
- Accepted manuscript online: 10 MAY 2013 02:13PM EST
- Manuscript Accepted: 2 MAY 2013
- Manuscript Received: 30 OCT 2012
- NIH (National Institute of Arthritis and Musculoskeletal and Skin Diseases Clinical Research Center). Grant Number: P60-AR-047884
- National Center for Research Resources Institutional Clinical and Translational Science Award program. Grant Number: 5 UL1-RR-026314-03
Additional Supporting Information may be found in the online version of this article.
|ART_38009_sm_SupplFigure1.docx||259K||Supplementary Figure 1. Multiple regression VCA scores vs. GM volume: Red areas are clusters showing reduced gray matter volume across all cSLE subjects that correlated with lower Z scores for the VCA domain.|
|ART_38009_sm_SupplFigure2.docx||295K||Supplementary Figure 2: Panel A shows regions with decreased GM volume in the cSLE-NCD vs. cSLE-NL comparison for ANCOVA models that did (green) or did not (red) include SLE duration as a covariate. Voxels where GM decreases for both models overlapped are colored yellow. The figure shows a high degree of overlap between the two models consistent with there being no overall association of GM volume decreases with disease duration. The lack of association between cumulative oral or IV steroid exposure and GM volume is demonstrated in Panel B, with decreased GM volume in the cSLE-NCD vs. cSLE-NL comparison for models that did (green) or did not (red) include cumulative oral and IV steroid doses as covariates. Again the large extent of overlap between these models (yellow) is consistent with differences in steroid exposure not being associated with decreased GM volume in the cSLE-NCD group. Note that the increased number of green voxels representing the model that included steroid dose as a covariate, suggests this model better accounted for overall non-specific variance even though the cumulative steroid dose (oral or IV) did not explain the reduction in gray matter volume when tested using multiple regression.|
|ART_38009_sm_SupplTable1.docx||36K||Supplementary Table 1: Controls vs. cSLE-NCD cluster statistics|
|ART_38009_sm_SupplTable2.docx||36K||Supplementary Table 2: cSLE-NL vs. cSLE-NCD cluster statistics|
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