• 1
    Cederholm T, Wretlind B, Hellstrom K, Andersson B, Engstrom L, Brismar K, et al.Enhanced generation of interleukins 1β and 6 may contribute to the cachexia of chronic disease.Am J Clin Nutr1997;65:87682.
  • 2
    Kotler DP.Cachexia.Ann Intern Med2000;133:62234.
  • 3
    Brindle JT, Antti H, Holmes E, Tranter G, Nicholson JK, Bethell HW, et al.Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics.Nat Med2002;8:143944.
  • 4
    Sitton NG, Dixon JS, Bird HA, Wright V.Serum biochemistry in rheumatoid-arthritis, seronegative arthropathies, osteoarthritis, SLE and normal subjects.Br J Rheumatol1987;26:1315.
  • 5
    Sitton NG, Dixon JS, Bird HA, Wright V.Serum and synovial fluid histidine: a comparison in rheumatoid arthritis and osteoarthritis.Rheumatol Int1986;6:2514.
  • 6
    Gobelet C, Gerster JC.Synovial fluid lactate levels in septic and non-septic arthritides.Ann Rheum Dis1984;43:7425.
  • 7
    Toms TE, Symmons DP, Kitas GD.Dyslipidaemia in rheumatoid arthritis: the role of inflammation, drugs, lifestyle and genetic factors.Curr Vasc Pharmacol2010;8:30126.
  • 8
    Steiner G, Urowitz MB.Lipid profiles in patients with rheumatoid arthritis: mechanisms and the impact of treatment.Semin Arthritis Rheum2009;38:37281.
  • 9
    Myasoedova E, Crowson CS, Kremers HM, Fitz-Gibbon PD, Therneau TM, Gabriel SE.Total cholesterol and LDL levels decrease before rheumatoid arthritis.Ann Rheum Dis2010;69:13104.
  • 10
    Kokkonen H, Soderstrom I, Rocklov J, Hallmans G, Lejon K, Dahlqvist SR.Up-regulation of cytokines and chemokines predates the onset of rheumatoid arthritis.Arthritis Rheum2010;62:38391.
  • 11
    Marchesi JR, Holmes E, Khan F, Kochhar S, Scanlan P, Shanahan F, et al.Rapid and noninvasive metabonomic characterization of inflammatory bowel disease.J Proteome Res2007;6:54651.
  • 12
    Young SP, Nessim M, Falciani F, Trevino V, Banerjee SP, Scott RA, et al.Metabolomic analysis of human vitreous humor differentiates ocular inflammatory disease.Mol Vis2009;15:12107.
  • 13
    Sinclair AB, Viant MR, Ball AK, Burdon MA, Walker EA, Stewart PM, et al.NMR-based metabolomic analysis of cerebrospinal fluid and serum in neurological diseases—a diagnostic tool?NMR Biomed2010;23:12332.
  • 14
    Kapoor SR, Filer A, Fitzpatrick MA, Fisher BA, Taylor PC, Buckley CD, et al.Metabolic profiling predicts response to anti–tumor necrosis factor α therapy in patients with rheumatoid arthritis.Arthritis Rheum2013;65:144856.
  • 15
    Raza K, Filer A.Predicting the development of RA in patients with early undifferentiated arthritis.Best Pract Res Clin Rheumatol2009;23:2536.
  • 16
    Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, et al.Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.Nature2009;457:9104.
  • 17
    Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al.The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis.Arthritis Rheum1988;31:31524.
  • 18
    Raza K, Breese M, Nightingale P, Kumar K, Potter T, Carruthers DM, et al.Predictive value of antibodies to cyclic citrullinated peptide in patients with very early inflammatory arthritis.J Rheumatol2005;32:2318.
  • 19
    Viant MR.Improved methods for the acquisition and interpretation of NMR metabolomic data.Biochem Biophys Res Commun2003;310:9438.
  • 20
    Parsons HM, Ludwig C, Gunther UL, Viant MR.Improved classification accuracy in 1- and 2-dimensional NMR metabolomics data using the variance stabilising generalised logarithm transformation.BMC Bioinformatics2007;8:234.
  • 21
    Martens H, Naes T.Multivariate calibration.New York:John Wiley & Sons;1989.
  • 22
    Chauchard F, Cogdill R, Roussel S, Roger JM, Bellon-Maurel V.Application of LS-SVM to non-linear phenomena in NIR spectroscopy: development of a robust and portable sensor for acidity prediction in grapes.Chemom Intell Lab Syst2004;71:14150.
  • 23
    Gavaghan CL, Wilson ID, Nicholson JK.Physiological variation in metabolic phenotyping and functional genomic studies: use of orthogonal signal correction and PLS-DA.FEBS Lett2002;530:1916.
  • 24
    Nicholson JK, Holmes E, Kinross JM, Darzi AW, Takats Z, Lindon JC.Metabolic phenotyping in clinical and surgical environments.Nature2012;491:38492.
  • 25
    Wishart DS, Tzur D, Knox C, Eisner R, Guo AC, Young N, et al.HMDB: the Human Metabolome Database.Nucleic Acids Res2007;35:D5216.
  • 26
    Weljie AM, Newton J, Mercier P, Carlson E, Slupsky CM.Targeted profiling: quantitative analysis of 1H NMR metabolomics data.Anal Chem2006;78:443042.
  • 27
    Nicholson JK, Foxall PJ, Spraul M, Farrant RD, Lindon JC.750 MHz 1H and 1H-13C NMR spectroscopy of human blood plasma.Anal Chem1995;67:793811.
  • 28
    Beckonert O, Keun HC, Ebbels TM, Bundy J, Holmes E, Lindon JC, et al.Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts.Nat Protoc2007;2:2692703.
  • 29
    Kirschenlohr HL, Griffin JL, Clarke SC, Rhydwen R, Grace AA, Schofield PM, et al.Proton NMR analysis of plasma is a weak predictor of coronary artery disease [published erratum appears in Nat Med 2006;12:862].Nat Med2006;12:70510.
  • 30
    Lauridsen MB, Bliddal H, Christensen R, Danneskiold-Samsoe B, Bennett R, Keun H, et al.1H NMR spectroscopy-based interventional metabolic phenotyping: a cohort study of rheumatoid arthritis patients.J Proteome Res2010;9:454553.
  • 31
    Madsen R, Lundstedt T, Gabrielsson J, Sennbro CJ, Alenius GM, Moritz T, et al.Diagnostic properties of metabolic perturbations in rheumatoid arthritis.Arthritis Res Ther2011;13:R19.
  • 32
    Weljie AM, Dowlatabadi R, Miller BJ, Vogel HJ, Jirik FR.An inflammatory arthritis-associated metabolite biomarker pattern revealed by 1H NMR spectroscopy.J Proteome Res2007;6:345664.
  • 33
    Naughton D, Whelan M, Smith EC, Williams R, Blake DR, Grootveld M.An investigation of the abnormal metabolic status of synovial fluid from patients with rheumatoid arthritis by high field proton nuclear magnetic resonance spectroscopy.FEBS Lett1993;317:1358.
  • 34
    Claxson A, Grootveld M, Chander C, Earl J, Haycock P, Mantle M, et al.Examination of the metabolic status of rat air pouch inflammatory exudate by high field proton NMR spectroscopy.Biochim Biophys Acta1999;1454:5770.
  • 35
    Van de Stadt LA, van Sijl AM, van Schaardenburg D, Nurmohamed MT.Dyslipidaemia in patients with seropositive arthralgia predicts the development of arthritis.Ann Rheum Dis2012;71:19156.
  • 36
    Park YB, Lee SK, Lee WK, Suh CH, Lee CW, Lee CH, et al.Lipid profiles in untreated patients with rheumatoid arthritis.J Rheumatol1999;26:17014.
  • 37
    Ahmed HM, Youssef M, Mosaad YM.Antibodies against oxidized low-density lipoprotein are associated with subclinical atherosclerosis in recent-onset rheumatoid arthritis.Clin Rheumatol2010;29:123743.
  • 38
    Toms TE, Panoulas VF, Douglas KM, Nightingale P, Smith JP, Griffiths H, et al.Are lipid ratios less susceptible to change with systemic inflammation than individual lipid components in patients with rheumatoid arthritis?Angiology2011;62:16775.
  • 39
    Dessein PH, Joffe BI, Stanwix A, Botha AS, Moomal Z.The acute phase response does not fully predict the presence of insulin resistance and dyslipidemia in inflammatory arthritis.J Rheumatol2002;29:4626.
  • 40
    Kavanaugh A.Dyslipoproteinaemia in a subset of patients with rheumatoid arthritis.Ann Rheum Dis1994;53:5512.
  • 41
    Hrnciarikova D, Hyspler R, Vyroubal P, Klemera P, Hronek M, Zadak Z.Serum lipids and neopterin in urine as new biomarkers of malnutrition and inflammation in the elderly.Nutrition2009;25:3038.
  • 42
    McCarey DW, McInnes LB, Madhok R, Hampson R, Scherbakova O, Ford I, et al.Trial of Atorvastatin in Rheumatoid Arthritis (TARA): double-blind, randomised placebo-controlled trial.Lancet2004;363:201521.
  • 43
    Leung BP, Sattar N, Crilly A, Prach M, McCarey DW, Payne H, et al.A novel anti-inflammatory role for simvastatin in inflammatory arthritis.J Immunol2003;170:152430.
  • 44
    Peters MJ, Vis M, van Halm VP, Wolbink GJ, Voskuyl AE, Lems WF, et al.Changes in lipid profile during infliximab and corticosteroid treatment in rheumatoid arthritis.Ann Rheum Dis2007;66:95861.
  • 45
    Van Halm VP, Nielen MM, Nurmohamed MT, van Schaardenburg D, Reesink HW, Voskuyl AE, et al.Lipids and inflammation: serial measurements of the lipid profile of blood donors who later developed rheumatoid arthritis.Ann Rheum Dis2007;66:1848.