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The patient, a 40-year-old man who had been diagnosed as having Ollier disease when he was child, presented with limb deformities and multiple masses in the hands and feet, which had been painful for several weeks. His medical history included corrective osteotomies for genu varum and leg length discrepancy. On physical examination, the patient was found to be small in stature, with oversized hands and numerous nodules on the fingers (left) and toes that were prominent and tender to palpation on the left thumb, index, middle, and little fingers and resulted in a limited range of motion. Radiographs of the hands revealed bilateral ulnar shortening and expansile intramedullary radiolucent lesions, with lobular contours, endosteal scalloping, and small foci of calcification, consistent with enchondroma (top right). Areas of cortical destruction with extension into the soft tissues were noted on the left hand. Phleboliths and soft tissue calcifications were not found. Fat-suppressed T2-weighted magnetic resonance imaging (MRI) of the hands showed well-circumscribed lobulated lesions of high signal intensity (bottom right), with thin peripheral and septal enhancement after intravenous administration of gadolinium. Results of whole-body MRI ruled out the presence of soft tissue hemangiomas or other associated malignancies, particularly of the brain and abdomen. Originally described in 1899, enchondromatosis is a rare, nonhereditary mesodermal dysplasia characterized by multiple cartilaginous foci distributed asymmetrically throughout the tubular and flat bones ([1, 2]). Although more common in Maffucci syndrome, malignant transformation into chondrosarcoma by 40 years of age has been reported in ∼25% of patients with Ollier disease ([2, 3]). Adult patients with Ollier disease generally seek medical attention for pain related to osteoarthritis caused by the deformities or sarcomatous transformation of an enchondroma. In this case, the patient's symptoms persisted despite medical treatment, but he refused surgical intervention. He is currently being followed up closely.