• 1
    Nagaraju K, Casciola-Rosen L, Lundberg I, Rawat R, Cutting S, Thapliyal R, et al.Activation of the endoplasmic reticulum stress response in autoimmune myositis: potential role in muscle fiber damage and dysfunction.Arthritis Rheum2005;52:182435.
  • 2
    Vitadello M, Doria A, Tarricone E, Ghirardello A, Gorza L.Myofiber stress-response in myositis: parallel investigations on patients and experimental animal models of muscle regeneration and systemic inflammation.Arthritis Res Ther2010;12:R52.
  • 3
    Nogalska A, Engel WK, Askanas V.Increased BACE1 mRNA and noncoding BACE1-antisense transcript in sporadic inclusion-body myositis muscle fibers—possibly caused by endoplasmic reticulum stress.Neurosci Lett2010;474:1403
  • 4
    Vattemi G, Engel WK, McFerrin J, Askanas V.Endoplasmic reticulum stress and unfolded protein response in inclusion body myositis muscle.Am J Pathol2004;164:17.
  • 5
    Li CK, Knopp P, Moncrieffe H, Singh B, Shah S, Nagaraju K, et al.Overexpression of MHC class I heavy chain protein in young skeletal muscle leads to severe myositis: implications for juvenile myositis.Am J Pathol2009;175:103040.
  • 6
    Nagaraju K, Raben N, Loeffler L, Parker T, Rochon PJ, Lee E, et al.Conditional up-regulation of MHC class I in skeletal muscle leads to self-sustaining autoimmune myositis and myositis-specific autoantibodies.Proc Natl Acad Sci U S A2000;97:920914.
  • 7
    Ong SE, Blagoev B, Kratchmarova I, Kristensen DB, Steen H, Pandey A, et al.Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics.Mol Cell Proteomics2002;1:37686.
  • 8
    Blagoev B, Kratchmarova I, Ong SE, Nielsen M, Foster LJ, Mann M.A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling.Nat Biotechnol2003;21:3158.
  • 9
    Kruger M, Moser M, Ussar S, Thievessen I, Luber CA, Forner F, et al.SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function.Cell2008;134:35364.
  • 10
    Sharma N, Medikayala S, Defour A, Rayavarapu S, Brown KJ, Hathout Y, et al.Use of quantitative membrane proteomics identifies a novel role of mitochondria in healing injured muscles.J Biol Chem2012,287:3045567.
  • 11
    Rayavarapu S, Coley W, Cakir E, Jahnke V, Takeda S, Aoki Y, et al.Identification of disease specific pathways using in vivo SILAC proteomics in dystrophin deficient mdx mouse.Mol Cell Proteomics2013;12:106173.
  • 12
    Baumeister W, Walz J, Zuhl F, Seemuller E.The proteasome: paradigm of a self-compartmentalizing protease.Cell1998;92:36780.
  • 13
    Zhang A, Williamson CD, Wong DS, Bullough MD, Brown KJ, Hathout Y, et al.Quantitative proteomic analyses of human cytomegalovirus-induced restructuring of endoplasmic reticulum-mitochondrial contacts at late times of infection.Mol Cell Proteomics2011;10:M111.009936.
  • 14
    Alger HM, Rayavarapu S, Nagaraju K.Measurement of activation of the endoplasmic reticulum stress response in autoimmune myositis.Methods Enzymol2011;489:20725.
  • 15
    Alger HM, Raben N, Pistilli E, Francia DL, Rawat R, Getnet D, et al.The role of TRAIL in mediating autophagy in myositis skeletal muscle: a potential nonimmune mechanism of muscle damage.Arthritis Rheum2011;63:344857.
  • 16
    Jahnke VE, van der Meulen JH, Johnston HK, Ghimbovschi S, Partridge T, Hoffman EP, et al.Metabolic remodeling agents show beneficial effects in the dystrophin-deficient mdx mouse model.Skelet Muscle2012;2:16.
  • 17
    Rayavarapu S, van der Meulen JH, Gordish-Dressman H, Hoffman EP, Nagaraju K, Knoblach SM.Characterization of dysferlin deficient SJL/J mice to assess preclinical drug efficacy: fasudil exacerbates muscle disease phenotype.PLoS One2010;5:e12981.
  • 18
    Spurney CF, Gordish-Dressman H, Guerron AD, Sali A, Pandey GS, Rawat R, et al.Preclinical drug trials in the mdx mouse: assessment of reliable and sensitive outcome measures.Muscle Nerve2009;39:591602.
  • 19
    Coley W, Rayavarapu S, Pandey GS, Sabina RL, van der Meulen JH, Ampong B, et al.The molecular basis of skeletal muscle weakness in a mouse model of inflammatory myopathy.Arthritis Rheum2012;64:37509.
  • 20
    Nader GA, Dastmalchi M, Alexanderson H, Grundtman C, Gernapudi R, Esbjornsson M, et al.A longitudinal, integrated, clinical, histological and mRNA profiling study of resistance exercise in myositis.Mol Med2010;16:45564.
  • 21
    Li J, Yin C, Okamoto H, Jaffe H, Oldfield EH, Zhuang Z, et al.proteomic analysis of inclusion body myositis.J Neuropathol Exp Neurol2006;65:82633.
  • 22
    Salajegheh M, Kong SW, Pinkus JL, Walsh RJ, Liao A, Nazareno R, et al.Interferon-stimulated gene 15 (ISG15) conjugates proteins in dermatomyositis muscle with perifascicular atrophy.Ann Neurol2010;67:5363.
  • 23
    Sela I, Milman Krentsis I, Shlomai Z, Sadeh M, Dabby R, Argov Z, et al.The proteomic profile of hereditary inclusion body myopathy.PLoS One2011;6:e16334.
  • 24
    Parker KC, Kong SW, Walsh RJ, Salajegheh M, Moghadaszadeh B, Amato AA, et al.Fast-twitch sarcomeric and glycolytic enzyme protein loss in inclusion body myositis.Muscle Nerve2009;39:73953.
  • 25
    Passadore I, Iadarola P, di Poto C, Giuliano S, Montecucco C, Cavagna L, et al.2-DE and LC-MS/MS for a comparative proteomic analysis of BALf from subjects with different subsets of inflammatory myopathies.J Proteome Res2009;8:233140.
  • 26
    Gong B, Cao Z, Zheng P, Vitolo OV, Liu S, Staniszewski A, et al.Ubiquitin hydrolase Uch-L1 rescues β-amyloid-induced decreases in synaptic function and contextual memory.Cell2006;126:77588.
  • 27
    Nogalska A, Engel WK, McFerrin J, Kokame K, Komano H, Askanas V.Homocysteine-induced endoplasmic reticulum protein (Herp) is up-regulated in sporadic inclusion-body myositis and in endoplasmic reticulum stress-induced cultured human muscle fibers.J Neurochem2006;96:14919.
  • 28
    Henriques-Pons A, Nagaraju K.Nonimmune mechanisms of muscle damage in myositis: role of the endoplasmic reticulum stress response and autophagy in the disease pathogenesis.Curr Opin Rheumatol2009;21:5817.
  • 29
    Lindsten K, de Vrij FM, Verhoef LG, Fischer DF, van Leeuwen FW, Hol EM, et al.Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation.J Cell Biol2002;157:41727.
  • 30
    Schwartz AL, Ciechanover A.Targeting proteins for destruction by the ubiquitin system: implications for human pathobiology.Annu Rev Pharmacol Toxicol2009;49:7396.
  • 31
    Ciechanover A, Brundin P.The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.Neuron2003;40:42746.
  • 32
    Medina R, Wing SS, Goldberg AL.Increase in levels of polyubiquitin and proteasome mRNA in skeletal muscle during starvation and denervation atrophy.Biochem J1995;307:6317.
  • 33
    Horton TM, Gannavarapu A, Blaney SM, D'Argenio DZ, Plon SE, Berg SL.Bortezomib interactions with chemotherapy agents in acute leukemia in vitro.Cancer Chemother Pharmacol2006;58:1323.
  • 34
    Sayers TJ, Brooks AD, Koh CY, Ma W, Seki N, Raziuddin A, et al.The proteasome inhibitor PS-341 sensitizes neoplastic cells to TRAIL-mediated apoptosis by reducing levels of c-FLIP.Blood2003;102:30310.
  • 35
    Neubert K, Meister S, Moser K, Weisel F, Maseda D, Amann K, et al.The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis.Nat Med2008;14:74855.
  • 36
    Caron AZ, Haroun S, Leblanc E, Trensz F, Guindi C, Amrani A, et al.The proteasome inhibitor MG132 reduces immobilization-induced skeletal muscle atrophy in mice.BMC Musculoskelet Disord2011;12:185.
  • 37
    Palombella VJ, Conner EM, Fuseler JW, Destree A, Davis JM, Laroux FS, et al.Role of the proteasome and NF-κB in streptococcal cell wall-induced polyarthritis.Proc Natl Acad Sci U S A1998;95:156716.
  • 38
    Amiri KI, Horton LW, LaFleur BJ, Sosman JA, Richmond A.Augmenting chemosensitivity of malignant melanoma tumors via proteasome inhibition: implication for bortezomib (VELCADE, PS-341) as a therapeutic agent for malignant melanoma.Cancer Res2004,64:49128.
  • 39
    Sunwoo JB, Chen Z, Dong G, Yeh N, Crowl Bancroft C, Sausville E, et al.Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-κB, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma.Clin Cancer Res2001;7:141928.
  • 40
    Thaloor D, Miller KJ, Gephart J, Mitchell PO, Pavlath GK.Systemic administration of the NF-κB inhibitor curcumin stimulates muscle regeneration after traumatic injury.Am J Physiol1999;277:C3209.
  • 41
    Jobin C, Hellerbrand C, Licato LL, Brenner DA, Sartor RB.Mediation by NF-κB of cytokine induced expression of intercellular adhesion molecule 1 (ICAM-1) in an intestinal epithelial cell line, a process blocked by proteasome inhibitors.Gut1998;42:77987.
  • 42
    Allport JR, Ding H, Collins T, Gerritsen ME, Luscinskas FW.Endothelial-dependent mechanisms regulate leukocyte transmigration: a process involving the proteasome and disruption of the vascular endothelial–cadherin complex at endothelial cell-to-cell junctions.J Exp Med1997;186:51727.