Presented by Dr. Rayavarapu in partial fulfillment of the requirements for a PhD degree, George Washington University, Washington, DC.
Activation of the Ubiquitin Proteasome Pathway in a Mouse Model of Inflammatory Myopathy: A Potential Therapeutic Target
Version of Record online: 27 NOV 2013
Copyright © 2013 by the American College of Rheumatology
Arthritis & Rheumatism
Volume 65, Issue 12, pages 3248–3258, December 2013
How to Cite
Rayavarapu, S., Coley, W., Van der Meulen, J. H., Cakir, E., Tappeta, K., Kinder, T. B., Dillingham, B. C., Brown, K. J., Hathout, Y. and Nagaraju, K. (2013), Activation of the Ubiquitin Proteasome Pathway in a Mouse Model of Inflammatory Myopathy: A Potential Therapeutic Target. Arthritis & Rheumatism, 65: 3248–3258. doi: 10.1002/art.38180
- Issue online: 27 NOV 2013
- Version of Record online: 27 NOV 2013
- Accepted manuscript online: 10 SEP 2013 03:35PM EST
- Manuscript Accepted: 27 AUG 2013
- Manuscript Received: 7 JAN 2013
- NIH (Intellectual and Developmental Disabilities Research Center [IDDRC]). Grant Number: P30-HD-40677
- National Center for Medical Rehabilitation Research/National Institute of Neurological Disorders and Stroke core. Grant Number: 2R24-HD-050846-06
- IDDRC core grant. Grant Number: 5P30-HD-040677-10
- National Center for Research Resources [George Washington University–Children's National Medical Center, Clinical and Translational Science Institute]. Grant Number: UL1-RR-031988
- Association Francaise Contre les Myopathies (Pre-Doctoral Fellowship)
- NIH. Grant Numbers: R01-AR-050478, 5U54-HD-053177, K26-OD-011171
- Muscular Dystrophy Association
- US Department of Defense. Grant Number: W81XWH-05-1-0616
Additional Supporting Information may be found in the online version of this article.
|ART_38180_sm_SupplFig1.tif||870K||Supplementary Figure 1. Pathways involved in the pathogenesis of myopathic muscle. Over expression of MHC class I leads to the accumulation of these molecules in the endoplasmic reticulum (ER) and in turn induces ER stress responses. Chronic ER stress activates the ubiquitin proteosome pathway, affects mitochondrial energy metabolism and disturbances in calcium homeostasis, and lead to myofiber degeneration.|
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