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ART_38180_sm_SupplFig1.tif870KSupplementary Figure 1. Pathways involved in the pathogenesis of myopathic muscle. Over expression of MHC class I leads to the accumulation of these molecules in the endoplasmic reticulum (ER) and in turn induces ER stress responses. Chronic ER stress activates the ubiquitin proteosome pathway, affects mitochondrial energy metabolism and disturbances in calcium homeostasis, and lead to myofiber degeneration.
ART_38180_sm_SupplTable1.pdf95KSupplementary Table

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