• 1
    Christmann RB, Sampaio-Barros P, Stifano G, Borges CL, de Carvalho CR, Kairalla R, et al.Association of interferon- and transforming growth factor β–regulated genes and macrophage activation with systemic sclerosis–related progressive lung fibrosis.Arthritis Rheumatol2014;66:71425.
  • 2
    Steen VD, Medsger TA.Changes in causes of death in systemic sclerosis, 1972-2002.Ann Rheum Dis2007;66:9404.
  • 3
    Daoussis D, Liossis SN, Tsamandas AC, Kalogeropoulou C, Paliogianni F, Sirinian C, et al.Effect of long-term treatment with rituximab on pulmonary function and skin fibrosis in patients with diffuse systemic sclerosis.Clin Exp Rheumatol2012;30:S1722.
  • 4
    Khanna D, Tseng CH, Farmani N, Steen V, Furst DE, Clements PJ, et al.Clinical course of lung physiology in patients with scleroderma and interstitial lung disease: analysis of the Scleroderma Lung Study placebo group.Arthritis Rheum2011;63:307885.
  • 5
    Tashkin DP, Elashoff R, Clements PJ, Goldin J, Roth MD, Furst DE, et al.Cyclophosphamide versus placebo in scleroderma lung disease.N Engl J Med2006;354:265566.
  • 6
    Kinsella MB, Smith EA, Miller KS, LeRoy EC, Silver RM.Spontaneous production of fibronectin by alveolar macrophages in patients with scleroderma.Arthritis Rheum1989;32:57783.
  • 7
    Kowal-Bielecka O, Kowal K, Highland KB, Silver RM.Bronchoalveolar lavage fluid in scleroderma interstitial lung disease: technical aspects and clinical correlations: review of the literature.Semin Arthritis Rheum2010;40:7388.
  • 8
    Andersen GN, Nilsson K, Nagaeva O, Rantapaa-Dahlqvist S, Sandstrom T, Mincheva-Nilsson L.Cytokine mRNA profile of alveolar T lymphocytes and macrophages in patients with systemic sclerosis suggests a local Tr1 response.Scand J Immunol2011;74:27281.
  • 9
    Ludwicka A, Ohba T, Trojanowska M, Yamakage A, Strange C, Smith EA, et al.Elevated levels of platelet derived growth factor and transforming growth factor-β1 in bronchoalveolar lavage fluid from patients with scleroderma.J Rheumatol1995;22:187683.
  • 10
    Hsu E, Shi H, Jordan RM, Lyons-Weiler J, Pilewski JM, Feghali-Bostwick CA.Lung tissues in patients with systemic sclerosis have gene expression patterns unique to pulmonary fibrosis and pulmonary hypertension.Arthritis Rheum2011;63:78394.
  • 11
    Lindahl GE, Stock CJ, Shi-Wen X, Leoni P, Sestini P, Howat SL, et al.Microarray profiling reveals suppressed interferon stimulated gene program in fibroblasts from scleroderma-associated interstitial lung disease.Respir Res2013;14:80.
  • 12
    Steen V, Domsic RT, Lucas M, Fertig N, Medsger TA Jr.A clinical and serologic comparison of African American and Caucasian patients with systemic sclerosis.Arthritis Rheum2012;64:298694.
  • 13
    Bogatkevich GS, Ludwicka-Bradley A, Highland KB, Hant F, Nietert PJ, Singleton CB, et al.Impairment of the antifibrotic effect of hepatocyte growth factor in lung fibroblasts from African Americans: possible role in systemic sclerosis.Arthritis Rheum2007;56:243242.
  • 14
    Brissett M, Veraldi KL, Pilewski JM, Medsger TA Jr, Feghali-Bostwick CA.Localized expression of tenascin in systemic sclerosis–associated pulmonary fibrosis and its regulation by insulin-like growth factor binding protein 3.Arthritis Rheum2012;64:27280.