• 1
    Hashimoto G, Aoki T, Nakamura H, Tanzawa K, Okada Y.Inhibition of ADAMTS4 (aggrecanase-1) by tissue inhibitors of metalloproteinases (TIMP-1, 2, 3 and 4).FEBS Lett2001;494:1925.
  • 2
    Kashiwagi M, Tortorella M, Nagase H, Brew K.TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5).J Biol Chem2001;276:125014.
  • 3
    Barksby HE, Hui W, Wappler I, Peters HH, Milner JM, Richards CD, et al.Interleukin-1 in combination with oncostatin M up-regulates multiple genes in chondrocytes: implications for cartilage destruction and repair.Arthritis Rheum2006;54:54050.
  • 4
    Rowan AD, Koshy PJ, Shingleton WD, Degnan BA, Heath JK, Vernallis AB, et al.Synergistic effects of glycoprotein 130 binding cytokines in combination with interleukin-1 on cartilage collagen breakdown.Arthritis Rheum2001;44:162032.
  • 5
    Cawston TE, Curry VA, Summers CA, Clark IM, Riley GP, Life PF, et al.The role of oncostatin M in animal and human connective tissue collagen turnover and its localization within the rheumatoid joint.Arthritis Rheum1998;41:176071.
  • 6
    Milner JM, Elliott SF, Cawston TE.Activation of procollagenases is a key control point in cartilage collagen degradation: interaction of serine and metalloproteinase pathways.Arthritis Rheum2001;44:208496.
  • 7
    Rowan AD, Hui W, Cawston TE, Richards CD.Adenoviral gene transfer of interleukin-1 in combination with oncostatin M induces significant joint damage in a murine model.Am J Pathol2003;162:197584.
  • 8
    Sen CK, Packer L.Antioxidant and redox regulation of gene transcription.FASEB J1996;10:70920.
  • 9
    Dean G, Young DA, Edwards DR, Clark IM.The human tissue inhibitor of metalloproteinases (TIMP)-1 gene contains repressive elements within the promoter and intron 1.J Biol Chem2000;275:3266471.
  • 10
    Litherland GJ, Dixon C, Lakey RL, Robson T, Jones D, Young DA, et al.Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol 3-kinase/Akt signaling-dependent.J Biol Chem2008;283:142219.
  • 11
    Tanos T, Marinissen MJ, Leskow FC, Hochbaum D, Martinetto H, Gutkind JS, et al.Phosphorylation of c-Fos by members of the p38 MAPK family: role in the AP-1 response to UV light.J Biol Chem2005;280:1884252.
  • 12
    Catterall JB, Carrere S, Koshy PJ, Degnan BA, Shingleton WD, Brinckerhoff CE, et al.Synergistic induction of matrix metalloproteinase 1 by interleukin-1α and oncostatin M in human chondrocytes involves signal transducer and activator of transcription and activator protein 1 transcription factors via a novel mechanism.Arthritis Rheum2001;44:2296310.
  • 13
    Bachmann J, Raue A, Schilling M, Becker V, Timmer J, Klingmuller U.Predictive mathematical models of cancer signalling pathways.J Intern Med2012;271:15565.
  • 14
    Morris AM, Watzky MA, Finke RG.Protein aggregation kinetics, mechanism, and curve-fitting: a review of the literature.Biochim Biophys Acta2009;1794:37597.
  • 15
    Noble D.Modeling the heart–from genes to cells to the whole organ.Science2002;295:167882.
  • 16
    Hucka M, Finney A, Sauro HM, Bolouri H, Doyle JC, Kitano H, et al.The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models.Bioinformatics2003;19:52431.
  • 17
    Wilkinson DJ.Stochastic modelling for systems biology. 2nd ed.London:Chapman & Hall/CRC Press;2011.
  • 18
    Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, et al.BioModels database: an enhanced, curated and annotated resource for published quantitative kinetic models.BMC Syst Biol2010;4:92.
  • 19
    Burrage PS, Mix KS, Brinckerhoff CE.Matrix metalloproteinases: role in arthritis.Front Biosci2006;11:52943.
  • 20
    Martel-Pelletier J, Raynauld JP, Pelletier JP.Quantitative imaging of the structural changes of osteoarthritis: an exciting challenge for the new millennium.Curr Rheumatol Rep2001;3:4656.
  • 21
    Linsley PS, Bolton-Hanson M, Horn D, Malik N, Kallestad JC, Ochs V, et al.Identification and characterization of cellular receptors for the growth regulator, oncostatin M.J Biol Chem1989;264:42829.
  • 22
    Gruber J, Vincent TL, Hermansson M, Bolton M, Wait R, Saklatvala J.Induction of interleukin-1 in articular cartilage by explantation and cutting.Arthritis Rheum2004;50:253946.
  • 23
    Legendre F, Dudhia J, Pujol JP, Bogdanowicz P.JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of type II collagen, aggrecan core, and link protein transcription in articular chondrocytes: association with a down-regulation of SOX9 expression.J Biol Chem2003;278:290312.
  • 24
    Stross C, Radtke S, Clahsen T, Gerlach C, Volkmer-Engert R, Schaper F, et al.Oncostatin M receptor-mediated signal transduction is negatively regulated by SOCS3 through a receptor tyrosine-independent mechanism.J Biol Chem2006;281:845868.
  • 25
    Elliott S, Hays E, Mayor M, Sporn M, Vincenti M.The triterpenoid CDDO inhibits expression of matrix metalloproteinase-1, matrix metalloproteinase-13 and Bcl-3 in primary human chondrocytes.Arthritis Res Ther2003;5:R28591.
  • 26
    Hwang SG, Yu SS, Poo H, Chun JS.c-Jun/activator protein-1 mediates interleukin-1β-induced dedifferentiation but not cyclooxygenase-2 expression in articular chondrocytes.J Biol Chem2005;280:297807.
  • 27
    Li J, Schmidt AM.Characterization and functional analysis of the promoter of RAGE, the receptor for advanced glycation end products.J Biol Chem1997;272:16498506.
  • 28
    Hoops S, Sahle S, Gauges R, Lee C, Pahle J, Simus N, et al.COPASI–a COmplex PAthway SImulator.Bioinformatics2006;22:306774.
  • 29
    Gillespie DT.Exact stochastic simulation of coupled chemical reactions.J Phys Chem1977;31:234061.
  • 30
    Gillespie CS, Wilkinson DJ, Proctor CJ, Shanley DP, Boys RJ, Kirkwood TB.Tools for the SBML community.Bioinformatics2006;22:6289.
  • 31
    Wickham H.ggplot2: elegant graphics for data analysis.New York:Springer;2009.
  • 32
    Funahashi A, Matsuoka Y, Jouraku A, Morohashi M, Kikuchi N, Kitano H.CellDesigner 3.5: a versatile modeling tool for biochemical networks.Proc IEEE2008;96:125465.
  • 33
    Le Novere N, Hucka M, Mi H, Moodie S, Schreiber F, Sorokin A, et al.The Systems Biology Graphical Notation [published erratum appear in Nat Biotechnol 2009;27:864].Nat Biotechnol2009;27:73541.
  • 34
    Ridley SH, Sarsfield SJ, Lee JC, Bigg HF, Cawston TE, Taylor DJ, et al.Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase: regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels.J Immunol1997;158:316573.
  • 35
    Milner JM, Patel A, Davidson RK, Swingler TE, Desilets A, Young DA, et al.Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis.Arthritis Rheum2010;62:195566.
  • 36
    Kobayashi M, Squires GR, Mousa A, Tanzer M, Zukor DJ, Antoniou J, et al.Role of interleukin-1 and tumor necrosis factor α in matrix degradation of human osteoarthritic cartilage.Arthritis Rheum2005;52:12835.
  • 37
    Apparailly F, Noel D, Millet V, Baker AH, Lisignoli G, Jacquet C, et al.Paradoxical effects of tissue inhibitor of metalloproteinases 1 gene transfer in collagen-induced arthritis.Arthritis Rheum2001;44:144454.
  • 38
    Milner JM, Cawston TE.Matrix metalloproteinase knockout studies and the potential use of matrix metalloproteinase inhibitors in the rheumatic diseases.Curr Drug Targets Inflamm Allergy2005;4:36375.
  • 39
    Bresnihan B.Treatment of rheumatoid arthritis with interleukin 1 receptor antagonist.Ann Rheum Dis1999;58:I968.
  • 40
    Rowan AD, Young DA.Collagenase gene regulation by pro-inflammatory cytokines in cartilage.Front Biosci2007;12:53650.