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Very early treatment with infliximab in addition to methotrexate in early, poor-prognosis rheumatoid arthritis reduces magnetic resonance imaging evidence of synovitis and damage, with sustained benefit after infliximab withdrawal: Results from a twelve-month randomized, double-blind, placebo-controlled trial (pages 27–35)Mark A. Quinn, Philip G. Conaghan, Philip J. O'Connor, Zunaid Karim, Adam Greenstein, Andrew Brown, Clare Brown, Alexander Fraser, Stephen Jarret and Paul Emery
Article first published online: 7 JAN 2005 | DOI: 10.1002/art.20712
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Early suppression of disease activity is essential for maintenance of work capacity in patients with recent-onset rheumatoid arthritis: Five-year experience from the FIN-RACo trial (pages 36–41)Kari Puolakka, Hannu Kautiainen, Timo Möttönen, Pekka Hannonen, Markku Korpela, Markku Hakala, Pentti Järvinen, Jari Ahonen, Sinikka Forsberg and Marjatta Leirisalo-Repo
Article first published online: 7 JAN 2005 | DOI: 10.1002/art.20716
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Presentation and analysis of data on radiographic outcome in clinical trials: Experience from the TEMPO study (pages 49–60)Désirée van der Heijde, Robert Landewé, Lars Klareskog, Vicente Rodríguez-Valverde, Lucas Settas, Ronald Pedersen and Saeed Fatenejad
Article first published online: 7 JAN 2005 | DOI: 10.1002/art.20775
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Evidence that anti–tumor necrosis factor therapy with both etanercept and infliximab induces apoptosis in macrophages, but not lymphocytes, in rheumatoid arthritis joints: Extended report (pages 61–72)Anca Irinel Catrina, Christina Trollmo, Erik af Klint, Marianne Engstrom, Jon Lampa, Ylva Hermansson, Lars Klareskog and Ann Kristin Ulfgren
Article first published online: 7 JAN 2005 | DOI: 10.1002/art.20764
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Increased CD4+ T cell infiltrates in rheumatoid arthritis–associated interstitial pneumonitis compared with idiopathic interstitial pneumonitis (pages 73–79)Carl Turesson, Eric L. Matteson, Thomas V. Colby, Zvezdana Vuk-Pavlovic, Robert Vassallo, Cornelia M. Weyand, Henry D. Tazelaar and Andrew H. Limper
Article first published online: 7 JAN 2005 | DOI: 10.1002/art.20765
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Interleukin-6 receptor shedding is enhanced by interleukin-1β and tumor necrosis factor α and is partially mediated by tumor necrosis factor α–converting enzyme in osteoblast-like cells (pages 84–93)Nathalie Franchimont, Cécile Lambert, Pascale Huynen, Clio Ribbens, Biserka Relic, Alain Chariot, Vincent Bours, Jacques Piette, Marie-Paule Merville and Michel Malaise
Article first published online: 7 JAN 2005 | DOI: 10.1002/art.20727
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Inhibition of interleukin-1β–induced cyclooxygenase 2 expression in human synovial fibroblasts by 15-deoxy-Δ12,14-prostaglandin J2 through a histone deacetylase–independent mechanism (pages 94–104)Katherine Farrajota, Saranette Cheng, Johanne Martel-Pelletier, Hassan Afif, Jean-Pierre Pelletier, Xinfang Li, Pierre Ranger and Hassan Fahmi
Article first published online: 7 JAN 2005 | DOI: 10.1002/art.20714
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Serum hyaluronan levels and radiographic knee and hip osteoarthritis in African Americans and Caucasians in the Johnston County Osteoarthritis Project (pages 105–111)Alan L. Elliott, Virginia B. Kraus, Gheorghe Luta, Thomas Stabler, Jordan B. Renner, Janice Woodard, Anca D. Dragomir, Charles G. Helmick, Marc C. Hochberg and Joanne M. Jordan
Article first published online: 7 JAN 2005 | DOI: 10.1002/art.20724
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Differential matrix degradation and turnover in early cartilage lesions of human knee and ankle joints (pages 112–119)Matthias Aurich, Ginette R. Squires, Agnes Reiner, Juergen A. Mollenhauer, Klaus E. Kuettner, A. Robin Poole and Ada A. Cole
Article first published online: 7 JAN 2005 | DOI: 10.1002/art.20740
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Role of interleukin-1 and tumor necrosis factor α in matrix degradation of human osteoarthritic cartilage (pages 128–135)Masahiko Kobayashi, Ginette R. Squires, Aisha Mousa, Michael Tanzer, David J. Zukor, John Antoniou, Ulrich Feige and A. Robin Poole
Article first published online: 7 JAN 2005 | DOI: 10.1002/art.20776
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Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes (pages 144–154)Denise L. Cecil, David M. Rose, Robert Terkeltaub and Ru Liu-Bryan
Article first published online: 7 JAN 2005 | DOI: 10.1002/art.20748
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Use of bone morphogenetic protein 2 and diffusion chambers to engineer cartilage tissue for the repair of defects in articular cartilage (pages 155–163)Masashi Nawata, Shigeyuki Wakitani, Hiroyuki Nakaya, Akira Tanigami, Toyokazu Seki, Yukio Nakamura, Naoto Saito, Kenji Sano, Eiko Hidaka and Kunio Takaoka
Article first published online: 7 JAN 2005 | DOI: 10.1002/art.20713
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Repair of articular cartilage defect by autologous transplantation of basic fibroblast growth factor gene–transduced chondrocytes with adeno-associated virus vector (pages 164–170)Naoki Yokoo, Tomoyuki Saito, Masaaki Uesugi, Naomi Kobayashi, Ke-Qin Xin, Kenji Okuda, Hiroaki Mizukami, Keiya Ozawa and Tomihisa Koshino
Article first published online: 7 JAN 2005 | DOI: 10.1002/art.20739
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Effect of inhibition of matrix metalloproteinases on cartilage loss in vitro and in a guinea pig model of osteoarthritis (pages 171–180)Massimo Sabatini, Christophe Lesur, Marie Thomas, Agnès Chomel, Philippe Anract, Guillaume de Nanteuil and Philippe Pastoureau
Article first published online: 7 JAN 2005 | DOI: 10.1002/art.20900
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Synovial fluid levels and serum pharmacokinetics in a large animal model following treatment with oral glucosamine at clinically relevant doses (pages 181–191)Sheila Laverty, John D. Sandy, Christophe Celeste, Pascal Vachon, Jean-Francois Marier and Anna H. K. Plaas
Article first published online: 7 JAN 2005 | DOI: 10.1002/art.20762
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Lipid peroxidation is enhanced in patients with systemic lupus erythematosus and is associated with arterial and renal disease manifestations (pages 192–200)Johan Frostegård, Elisabet Svenungsson, Ruihua Wu, Iva Gunnarsson, Ingrid E. Lundberg, Lars Klareskog, Sohvi Hörkkö and Joseph L. Witztum
Article first published online: 7 JAN 2005 | DOI: 10.1002/art.20780
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Increase in activated CD8+ T lymphocytes expressing perforin and granzyme B correlates with disease activity in patients with systemic lupus erythematosus (pages 201–211)Patrick Blanco, Vincent Pitard, Jean-François Viallard, Jean-Luc Taupin, Jean-Luc Pellegrin and Jean-François Moreau
Article first published online: 7 JAN 2005 | DOI: 10.1002/art.20745
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Association of a functional single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosus (pages 219–224)Gisela Orozco, Elena Sánchez, Miguel A. González-Gay, Miguel A. López-Nevot, Belén Torres, Rafael Cáliz, Norberto Ortego-Centeno, Juan Jiménez-Alonso, Dora Pascual-Salcedo, Alejandro Balsa, Rosario de Pablo, Antonio Nuñez-Roldan, Ma Francisca González-Escribano and Javier Martín
Article first published online: 7 JAN 2005 | DOI: 10.1002/art.20771
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Mature dendritic cells readily break tolerance in normal mice but do not lead to disease expression (pages 225–238)Maria Georgiev, Lucila M. A. Agle, Jia Li Chu, Keith B. Elkon and Dalit Ashany
Article first published online: 7 JAN 2005 | DOI: 10.1002/art.20759
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Antibodies against cyclic citrullinated peptide are associated with HLA–DR4 in simplex and multiplex polyarticular-onset juvenile rheumatoid arthritis (pages 239–246)Elizabeth D. Ferucci, Darcy S. Majka, Lezlie A. Parrish, Marta B. Moroldo, Mary Ryan, Murray Passo, Susan D. Thompson, Kevin D. Deane, Marian Rewers, William P. Arend, David N. Glass, Jill M. Norris and V. Michael Holers
Article first published online: 7 JAN 2005 | DOI: 10.1002/art.20773
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Association of SLC11A1 (NRAMP1) with persistent oligoarticular and polyarticular rheumatoid factor–negative juvenile idiopathic arthritis in Finnish patients: Haplotype analysis in Finnish families (pages 247–256)Jonathan A. Runstadler, Hanna Säilä, Anneli Savolainen, Marjatta Leirisalo-Repo, Kimmo Aho, Eva Tuomilehto-Wolf, Jaakko Tuomilehto and Michael F. Seldin
Article first published online: 7 JAN 2005 | DOI: 10.1002/art.20772
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Small interfering RNA inhibition of SPARC attenuates the profibrotic effect of transforming growth factor β1 in cultured normal human fibroblasts (pages 257–261)Xiaodong Zhou, Filemon K. Tan, Xinjian Guo, Debra Wallis, Dianna M. Milewicz, Sarah Xue and Frank C. Arnett
Article first published online: 7 JAN 2005 | DOI: 10.1002/art.20785
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A locus on chromosome 9p predisposes to a specific disease manifestation, acute anterior uveitis, in ankylosing spondylitis, a genetically complex, multisystem, inflammatory disease (pages 269–274)Tammy M. Martin, Ge Zhang, Jingchun Luo, Li Jin, Trudy M. Doyle, Barbara M. Rajska, Jessica E. Coffman, Justine R. Smith, Matthias D. Becker, Friederike Mackensen, Muhammad A. Khan, Ralph D. Levinson, H. Ralph Schumacher, N. Kevin Wade, James T. Rosenbaum and John D. Reveille
Article first published online: 7 JAN 2005 | DOI: 10.1002/art.20777
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Successful treatment of psoriatic onycho-pachydermo periostitis (POPP) with adalimumab (pages 280–282)T. Bongartz, P. Härle, S. Friedrich, S. Karrer, T. Vogt, A. Seitz and U. Müller-Ladner
Article first published online: 7 JAN 2005 | DOI: 10.1002/art.20763
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Effects of sevelamer and calcium-based phosphate binders on uric acid concentrations in patients undergoing hemodialysis: A randomized clinical trial (pages 290–295)Jay P. Garg, Scott Chasan-Taber, Andrew Blair, Melissa Plone, Juergen Bommer, Paolo Raggi and Glenn M. Chertow
Article first published online: 7 JAN 2005 | DOI: 10.1002/art.20781
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Ambulatory monitoring of physical activity and symptoms in fibromyalgia and chronic fatigue syndrome (pages 296–303)Willem J. Kop, Angela Lyden, Ali A. Berlin, Kirsten Ambrose, Cara Olsen, Richard H. Gracely, David A. Williams and Daniel J. Clauw
Article first published online: 7 JAN 2005 | DOI: 10.1002/art.20779
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Diagnostic value of sonography in patients with suspected carpal tunnel syndrome: A prospective study (pages 304–311)Hans-Rudolf Ziswiler, Stephan Reichenbach, Esther Vögelin, Lucas M. Bachmann, Peter M. Villiger and Peter Jüni
Article first published online: 7 JAN 2005 | DOI: 10.1002/art.20723
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Opioid use by patients in an orthopedics spine clinic (pages 312–321)Maren L. Mahowald, Jasvinder A. Singh and Peter Majeski
Article first published online: 7 JAN 2005 | DOI: 10.1002/art.20784
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The non–major histocompatibility complex quantitative trait locus Cia10 contains a major arthritis gene and regulates disease severity, pannus formation, and joint damage (pages 322–332)Max Brenner, Hsiang-Chi Meng, Nuriza C. Yarlett, Marie M. Griffiths, Elaine F. Remmers, Ronald L. Wilder and Pércio S. Gulko
Article first published online: 7 JAN 2005 | DOI: 10.1002/art.20782
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Reduction of the incidence and severity of collagen-induced arthritis by constitutive Nur77 expression in the T cell lineage (pages 333–338)Swanthri De Silva, Shuhua Han, Xuejun Zhang, David P. Huston, Astar Winoto and Biao Zheng
Article first published online: 7 JAN 2005 | DOI: 10.1002/art.20736
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Thrombospondin 1 as an effective gene therapeutic strategy in collagen-induced arthritis (pages 339–344)I-Ming Jou, Ai-Li Shiau, Shih-Yao Chen, Chrong-Reen Wang, Dar-Bin Shieh, Ching-Shan Tsai and Chao-Liang Wu
Article first published online: 7 JAN 2005 | DOI: 10.1002/art.20746
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Suppression of the onset and progression of collagen-induced arthritis by chebulagic acid screened from a natural product library (pages 345–353)Sang-Ik Lee, Pung-Mi Hyun, Seung-Hyung Kim, Kyoung-Shin Kim, Sang-Keun Lee, Byoung-Soo Kim, Pil Jae Maeng and Jong-Soon Lim
Article first published online: 7 JAN 2005 | DOI: 10.1002/art.20715