Arthritis & Rheumatism

© 2012 American College of Rheumatology

Cover image for Vol. 63 Issue 12

December 2011

Volume 63, Issue 12

Pages 3649–4094

  1. In This Issue

    1. Top of page
    2. In This Issue
    3. Special Article
    4. Commentary
    5. Editorials
    6. Rheumatoid Arthritis
    7. Spondylarthritis
    8. Experimental Arthritis
    9. Osteoarthritis
    10. Clinical Images
    11. Cartilage and Disc Biology
    12. Clinical Images
    13. Bone Biology
    14. Systemic Lupus Erythematosus
    15. Antiphospholipid Syndrome
    16. Systemic Sclerosis
    17. Vasculitis
    18. Gout
    19. Autoinflammatory Disease
    20. Radiology
    21. Erratum
    22. Concise Communication
    23. Letters
    24. Late-Breaking Abstracts
    25. Reviewers
    26. Contents, Volume 63, 2011
    27. ACR Announcements
    1. In this issue

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.33474

  2. Special Article

    1. Top of page
    2. In This Issue
    3. Special Article
    4. Commentary
    5. Editorials
    6. Rheumatoid Arthritis
    7. Spondylarthritis
    8. Experimental Arthritis
    9. Osteoarthritis
    10. Clinical Images
    11. Cartilage and Disc Biology
    12. Clinical Images
    13. Bone Biology
    14. Systemic Lupus Erythematosus
    15. Antiphospholipid Syndrome
    16. Systemic Sclerosis
    17. Vasculitis
    18. Gout
    19. Autoinflammatory Disease
    20. Radiology
    21. Erratum
    22. Concise Communication
    23. Letters
    24. Late-Breaking Abstracts
    25. Reviewers
    26. Contents, Volume 63, 2011
    27. ACR Announcements
    1. Quality measurement and improvement in rheumatology: Rheumatoid arthritis as a case study (pages 3649–3660)

      Sonali P. Desai and Jinoos Yazdany

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30605

  3. Commentary

    1. Top of page
    2. In This Issue
    3. Special Article
    4. Commentary
    5. Editorials
    6. Rheumatoid Arthritis
    7. Spondylarthritis
    8. Experimental Arthritis
    9. Osteoarthritis
    10. Clinical Images
    11. Cartilage and Disc Biology
    12. Clinical Images
    13. Bone Biology
    14. Systemic Lupus Erythematosus
    15. Antiphospholipid Syndrome
    16. Systemic Sclerosis
    17. Vasculitis
    18. Gout
    19. Autoinflammatory Disease
    20. Radiology
    21. Erratum
    22. Concise Communication
    23. Letters
    24. Late-Breaking Abstracts
    25. Reviewers
    26. Contents, Volume 63, 2011
    27. ACR Announcements
    1. Lupus: How much “complexity” is really (just) genetic heterogeneity? (pages 3661–3664)

      Yanick J. Crow

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30603

  4. Editorials

    1. Top of page
    2. In This Issue
    3. Special Article
    4. Commentary
    5. Editorials
    6. Rheumatoid Arthritis
    7. Spondylarthritis
    8. Experimental Arthritis
    9. Osteoarthritis
    10. Clinical Images
    11. Cartilage and Disc Biology
    12. Clinical Images
    13. Bone Biology
    14. Systemic Lupus Erythematosus
    15. Antiphospholipid Syndrome
    16. Systemic Sclerosis
    17. Vasculitis
    18. Gout
    19. Autoinflammatory Disease
    20. Radiology
    21. Erratum
    22. Concise Communication
    23. Letters
    24. Late-Breaking Abstracts
    25. Reviewers
    26. Contents, Volume 63, 2011
    27. ACR Announcements
    1. Nongenomic glucocorticoid signaling: New targets for immunosuppressive therapy? (pages 3665–3667)

      J. Leonard M. Schoneveld, Ruth D. Fritsch-Stork and Johannes W. J. Bijlsma

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30635

    2. Interleukin-23: A central cytokine in the pathogenesis of spondylarthritis (pages 3668–3671)

      J. S. Hill Gaston, Jane C. Goodall and Dominique Baeten

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30600

  5. Rheumatoid Arthritis

    1. Top of page
    2. In This Issue
    3. Special Article
    4. Commentary
    5. Editorials
    6. Rheumatoid Arthritis
    7. Spondylarthritis
    8. Experimental Arthritis
    9. Osteoarthritis
    10. Clinical Images
    11. Cartilage and Disc Biology
    12. Clinical Images
    13. Bone Biology
    14. Systemic Lupus Erythematosus
    15. Antiphospholipid Syndrome
    16. Systemic Sclerosis
    17. Vasculitis
    18. Gout
    19. Autoinflammatory Disease
    20. Radiology
    21. Erratum
    22. Concise Communication
    23. Letters
    24. Late-Breaking Abstracts
    25. Reviewers
    26. Contents, Volume 63, 2011
    27. ACR Announcements
    1. Hepcidin and hemoglobin content parameters in the diagnosis of iron deficiency in rheumatoid arthritis patients with anemia (pages 3672–3680)

      Susanne van Santen, Edmée C. van Dongen-Lases, Femmie de Vegt, Coby M. M. Laarakkers, Piet L. C. M. van Riel, Annelies E. van Ede and Dorine W. Swinkels

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30623

    2. Inflammation and autoantibody markers identify rheumatoid arthritis patients with enhanced clinical benefit following rituximab treatment (pages 3681–3691)

      Preeti Lal, Zheng Su, Cecile T. J. Holweg, Gregg J. Silverman, Sergio Schwartzman, Ariella Kelman, Simon Read, Greg Spaniolo, John G. Monroe, Timothy W. Behrens and Michael J. Townsend

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30596

    3. Blood memory B cells are disturbed and predict the response to rituximab in patients with rheumatoid arthritis (pages 3692–3701)

      Jérémie Sellam, Stéphanie Rouanet, Houria Hendel-Chavez, Karim Abbed, Jean Sibilia, Jacques Tebib, Xavier Le Loët, Bernard Combe, Maxime Dougados, Xavier Mariette and Yassine Taoufik

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30599

    4. Joint damage in rheumatoid arthritis progresses in remission according to the Disease Activity Score in 28 joints and is driven by residual swollen joints (pages 3702–3711)

      Daniel Aletaha and Josef S. Smolen

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30634

    5. Significant improvement in synovitis, osteitis, and bone erosion following golimumab and methotrexate combination therapy as compared with methotrexate alone: A magnetic resonance imaging study of 318 methotrexate-naive rheumatoid arthritis patients (pages 3712–3722)

      Mikkel Østergaard, Paul Emery, Philip G. Conaghan, Roy Fleischmann, Elizabeth C. Hsia, Weichun Xu and Mahboob U. Rahman

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30592

    6. Antibody response is reduced following vaccination with 7-valent conjugate pneumococcal vaccine in adult methotrexate-treated patients with established arthritis, but not those treated with tumor necrosis factor inhibitors (pages 3723–3732)

      Meliha Crnkic Kapetanovic, Carmen Roseman, Göran Jönsson, Lennart Truedsson, Tore Saxne and Pierre Geborek

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30580

    7. Association of the HLA–DRB1 epitope LA67, 74 with rheumatoid arthritis and citrullinated vimentin binding (pages 3733–3739)

      Brian M. Freed, Ronald P. Schuyler and Michael T. Aubrey

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30636

    8. Crystal structure of an arthritogenic anticollagen immune complex (pages 3740–3748)

      Doreen Dobritzsch, Ingrid Lindh, Hüseyin Uysal, Kutty S. Nandakumar, Harald Burkhardt, Gunter Schneider and Rikard Holmdahl

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30611

    9. Enhanced secretion of leukocyte-associated immunoglobulin-like receptor 2 (LAIR-2) and soluble LAIR-1 in rheumatoid arthritis: LAIR-2 is a more efficient antagonist of the LAIR-1–collagen inhibitory interaction than is soluble LAIR-1 (pages 3749–3757)

      Marloes J. M. Olde Nordkamp, Joël A. G. van Roon, Max Douwes, Talitha de Ruiter, Rolf T. Urbanus and Linde Meyaard

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30612

    10. Development of a novel recombinant biotherapeutic with applications in targeted therapy of human arthritis (pages 3758–3767)

      Panagiotis Kamperidis, Tahereh Kamalati, Mathieu Ferrari, Margaret Jones, Toby Garrood, Malcolm D. Smith, Soraya Diez-Posada, Chris Hughes, Ciara Finucane, Stephen Mather, Ahuva Nissim, Andrew J. T. George and Costantino Pitzalis

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30650

    11. Modulation of matrix metalloproteinase production by rheumatoid arthritis synovial fibroblasts after cadherin 11 engagement (pages 3768–3778)

      Erika H. Noss, Sook Kyung Chang, Gerald F. M. Watts and Michael B. Brenner

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30630

    12. Origin and functional activity of the membrane-bound glucocorticoid receptor (pages 3779–3788)

      Cindy Strehl, Timo Gaber, Mark Löwenberg, Daniel W. Hommes, Auke P. Verhaar, Saskia Schellmann, Martin Hahne, Monique Fangradt, Markus Wagegg, Paula Hoff, Alexander Scheffold, Cornelia M. Spies, Gerd-Rüdiger Burmester and Frank Buttgereit

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30637

  6. Spondylarthritis

    1. Top of page
    2. In This Issue
    3. Special Article
    4. Commentary
    5. Editorials
    6. Rheumatoid Arthritis
    7. Spondylarthritis
    8. Experimental Arthritis
    9. Osteoarthritis
    10. Clinical Images
    11. Cartilage and Disc Biology
    12. Clinical Images
    13. Bone Biology
    14. Systemic Lupus Erythematosus
    15. Antiphospholipid Syndrome
    16. Systemic Sclerosis
    17. Vasculitis
    18. Gout
    19. Autoinflammatory Disease
    20. Radiology
    21. Erratum
    22. Concise Communication
    23. Letters
    24. Late-Breaking Abstracts
    25. Reviewers
    26. Contents, Volume 63, 2011
    27. ACR Announcements
    1. Radiographic progression is associated with resolution of systemic inflammation in patients with axial spondylarthritis treated with tumor necrosis factor α inhibitors: A study of radiographic progression, inflammation on magnetic resonance imaging, and circulating biomarkers of inflammation, angiogenesis, and cartilage and bone turnover (pages 3789–3800)

      Susanne Juhl Pedersen, Inge Juul Sørensen, Robert G. W. Lambert, Kay-Geert A. Hermann, Patrick Garnero, Julia Sidenius Johansen, Ole Rintek Madsen, Annette Hansen, Michael Sejer Hansen, Gorm Thamsborg, Lis Smedegaard Andersen, Ole Majgaard, Anne Gitte Loft, Jon Erlendsson, Karsten H. Asmussen, Anne Grethe Jurik, Jakob Møller, Maria Hasselquist, Dorrit Mikkelsen and Mikkel Østergaard

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30627

    2. Tumor necrosis factor promoter polymorphism TNF*-857 is a risk allele for psoriatic arthritis independent of the PSORS1 locus (pages 3801–3806)

      Emiliano Giardina, Ulrike Hüffmeier, Jaya Ravindran, Frank Behrens, Tiziana Lepre, Neil J. McHugh, Eleanor Korendowych, Harald Burkhardt, Giuseppe Novelli and André Reis

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30591

    3. Ankylosing spondylitis macrophage production of higher levels of interleukin-23 in response to lipopolysaccharide without induction of a significant unfolded protein response (pages 3807–3817)

      Ling Zeng, Mary J. Lindstrom and Judith A. Smith

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30593

  7. Experimental Arthritis

    1. Top of page
    2. In This Issue
    3. Special Article
    4. Commentary
    5. Editorials
    6. Rheumatoid Arthritis
    7. Spondylarthritis
    8. Experimental Arthritis
    9. Osteoarthritis
    10. Clinical Images
    11. Cartilage and Disc Biology
    12. Clinical Images
    13. Bone Biology
    14. Systemic Lupus Erythematosus
    15. Antiphospholipid Syndrome
    16. Systemic Sclerosis
    17. Vasculitis
    18. Gout
    19. Autoinflammatory Disease
    20. Radiology
    21. Erratum
    22. Concise Communication
    23. Letters
    24. Late-Breaking Abstracts
    25. Reviewers
    26. Contents, Volume 63, 2011
    27. ACR Announcements
    1. Immunization with Porphyromonas gingivalis enolase induces autoimmunity to mammalian α-enolase and arthritis in DR4-IE–transgenic mice (pages 3818–3823)

      Andrew J. Kinloch, Saba Alzabin, William Brintnell, Elizabeth Wilson, Lillian Barra, Natalia Wegner, David A. Bell, Ewa Cairns and Patrick J. Venables

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30639

    2. Early diagnosis of arthritis in mice with collagen-induced arthritis, using a fluorogenic matrix metalloproteinase 3–specific polymeric probe (pages 3824–3832)

      Ju Hee Ryu, Aeju Lee, Jun-Uk Chu, Heebeom Koo, Chang-Yong Ko, Han Sung Kim, Soo-Young Yoon, Byung-Soo Kim, Kuiwon Choi, Ick Chan Kwon, Kwangmeyung Kim and Inchan Youn

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30628

    3. Overexpression of SPACIA1/SAAL1, a newly identified gene that is involved in synoviocyte proliferation, accelerates the progression of synovitis in mice and humans (pages 3833–3842)

      Tomoo Sato, Ryoji Fujii, Koji Konomi, Naoko Yagishita, Satoko Aratani, Natsumi Araya, Hiroyuki Aono, Kazuo Yudoh, Noboru Suzuki, Moroe Beppu, Yoshihisa Yamano, Kusuki Nishioka and Toshihiro Nakajima

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30617

  8. Osteoarthritis

    1. Top of page
    2. In This Issue
    3. Special Article
    4. Commentary
    5. Editorials
    6. Rheumatoid Arthritis
    7. Spondylarthritis
    8. Experimental Arthritis
    9. Osteoarthritis
    10. Clinical Images
    11. Cartilage and Disc Biology
    12. Clinical Images
    13. Bone Biology
    14. Systemic Lupus Erythematosus
    15. Antiphospholipid Syndrome
    16. Systemic Sclerosis
    17. Vasculitis
    18. Gout
    19. Autoinflammatory Disease
    20. Radiology
    21. Erratum
    22. Concise Communication
    23. Letters
    24. Late-Breaking Abstracts
    25. Reviewers
    26. Contents, Volume 63, 2011
    27. ACR Announcements
    1. Differences in multijoint radiographic osteoarthritis phenotypes among African Americans and Caucasians: The Johnston County Osteoarthritis Project (pages 3843–3852)

      Amanda E. Nelson, Jordan B. Renner, Todd A. Schwartz, Virginia B. Kraus, Charles G. Helmick and Joanne M. Jordan

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30610

    2. Asymmetric loading and bone mineral density at the asymptomatic knees of patients with unilateral hip osteoarthritis (pages 3853–3858)

      Najia Shakoor, Anisha Dua, Laura E. Thorp, Rachel A. Mikolaitis, Markus A. Wimmer, Kharma C. Foucher, Louis F. Fogg and Joel A. Block

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30626

    3. Independent association of joint space narrowing and osteophyte formation at the knee with health-related quality of life in Japan: A cross-sectional study (pages 3859–3864)

      Shigeyuki Muraki, Hiroyuki Oka, Toru Akune, Yoshio En-Yo, Munehito Yoshida, Takao Suzuki, Hideyo Yoshida, Hideaki Ishibashi, Fumiaki Tokimura, Seizo Yamamoto, Kozo Nakamura, Hiroshi Kawaguchi and Noriko Yoshimura

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30641

    4. R-spondins are newly recognized players in osteoarthritis that regulate Wnt signaling in osteoblasts (pages 3865–3875)

      Élie Abed, Thomas F. Chan, Aline Delalandre, Johanne Martel-Pelletier, Jean-Pierre Pelletier and Daniel Lajeunesse

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30625

  9. Clinical Images

    1. Top of page
    2. In This Issue
    3. Special Article
    4. Commentary
    5. Editorials
    6. Rheumatoid Arthritis
    7. Spondylarthritis
    8. Experimental Arthritis
    9. Osteoarthritis
    10. Clinical Images
    11. Cartilage and Disc Biology
    12. Clinical Images
    13. Bone Biology
    14. Systemic Lupus Erythematosus
    15. Antiphospholipid Syndrome
    16. Systemic Sclerosis
    17. Vasculitis
    18. Gout
    19. Autoinflammatory Disease
    20. Radiology
    21. Erratum
    22. Concise Communication
    23. Letters
    24. Late-Breaking Abstracts
    25. Reviewers
    26. Contents, Volume 63, 2011
    27. ACR Announcements
    1. Clinical images: Lacrimal gland and renal involvement in IgG4-related sclerosing disease (page 3875)

      Bao-Bao Hsu, Ning-Sheng Lai and Chien-Hsueh Tung

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30622

  10. Cartilage and Disc Biology

    1. Top of page
    2. In This Issue
    3. Special Article
    4. Commentary
    5. Editorials
    6. Rheumatoid Arthritis
    7. Spondylarthritis
    8. Experimental Arthritis
    9. Osteoarthritis
    10. Clinical Images
    11. Cartilage and Disc Biology
    12. Clinical Images
    13. Bone Biology
    14. Systemic Lupus Erythematosus
    15. Antiphospholipid Syndrome
    16. Systemic Sclerosis
    17. Vasculitis
    18. Gout
    19. Autoinflammatory Disease
    20. Radiology
    21. Erratum
    22. Concise Communication
    23. Letters
    24. Late-Breaking Abstracts
    25. Reviewers
    26. Contents, Volume 63, 2011
    27. ACR Announcements
    1. Identification of cell surface–specific markers to target human nucleus pulposus cells: Expression of carbonic anhydrase XII varies with age and degeneration (pages 3876–3886)

      Karen A. Power, Sibylle Grad, Joost P. H. J. Rutges, Laura B. Creemers, Mattie H. P. van Rijen, Peadar O'Gaora, J. Gerard Wall, Mauro Alini, Abhay Pandit and William M. Gallagher

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30607

    2. The role of calcified cartilage and subchondral bone in the initiation and progression of ochronotic arthropathy in alkaptonuria (pages 3887–3896)

      A. M. Taylor, A. Boyde, P. J. M. Wilson, J. C. Jarvis, J. S. Davidson, J. A. Hunt, L. R. Ranganath and J. A. Gallagher

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30606

  11. Clinical Images

    1. Top of page
    2. In This Issue
    3. Special Article
    4. Commentary
    5. Editorials
    6. Rheumatoid Arthritis
    7. Spondylarthritis
    8. Experimental Arthritis
    9. Osteoarthritis
    10. Clinical Images
    11. Cartilage and Disc Biology
    12. Clinical Images
    13. Bone Biology
    14. Systemic Lupus Erythematosus
    15. Antiphospholipid Syndrome
    16. Systemic Sclerosis
    17. Vasculitis
    18. Gout
    19. Autoinflammatory Disease
    20. Radiology
    21. Erratum
    22. Concise Communication
    23. Letters
    24. Late-Breaking Abstracts
    25. Reviewers
    26. Contents, Volume 63, 2011
    27. ACR Announcements
    1. Clinical images: Epidural hematoma in ankylosing spondylitis (page 3896)

      Seok Won Kim and Hyun-Sook Kim

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30643

  12. Bone Biology

    1. Top of page
    2. In This Issue
    3. Special Article
    4. Commentary
    5. Editorials
    6. Rheumatoid Arthritis
    7. Spondylarthritis
    8. Experimental Arthritis
    9. Osteoarthritis
    10. Clinical Images
    11. Cartilage and Disc Biology
    12. Clinical Images
    13. Bone Biology
    14. Systemic Lupus Erythematosus
    15. Antiphospholipid Syndrome
    16. Systemic Sclerosis
    17. Vasculitis
    18. Gout
    19. Autoinflammatory Disease
    20. Radiology
    21. Erratum
    22. Concise Communication
    23. Letters
    24. Late-Breaking Abstracts
    25. Reviewers
    26. Contents, Volume 63, 2011
    27. ACR Announcements
    1. Co-opting endogenous immunoglobulin for the regulation of inflammation and osteoclastogenesis in humans and mice (pages 3897–3907)

      Lindsay M. MacLellan, Jennifer Montgomery, Fujimi Sugiyama, Susan M. Kitson, Katja Thümmler, Gregg J. Silverman, Stephen A. Beers, Robert J. B. Nibbs, Iain B. McInnes and Carl S. Goodyear

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30629

    2. Distinguishing the proapoptotic and antiresorptive functions of risedronate in murine osteoclasts: Role of the Akt pathway and the ERK/Bim axis (pages 3908–3917)

      Takumi Matsumoto, Yuichi Nagase, Mitsuyasu Iwasawa, Tetsuro Yasui, Hironari Masuda, Yuho Kadono, Kozo Nakamura and Sakae Tanaka

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30646

  13. Systemic Lupus Erythematosus

    1. Top of page
    2. In This Issue
    3. Special Article
    4. Commentary
    5. Editorials
    6. Rheumatoid Arthritis
    7. Spondylarthritis
    8. Experimental Arthritis
    9. Osteoarthritis
    10. Clinical Images
    11. Cartilage and Disc Biology
    12. Clinical Images
    13. Bone Biology
    14. Systemic Lupus Erythematosus
    15. Antiphospholipid Syndrome
    16. Systemic Sclerosis
    17. Vasculitis
    18. Gout
    19. Autoinflammatory Disease
    20. Radiology
    21. Erratum
    22. Concise Communication
    23. Letters
    24. Late-Breaking Abstracts
    25. Reviewers
    26. Contents, Volume 63, 2011
    27. ACR Announcements
    1. A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus (pages 3918–3930)

      Richard Furie, Michelle Petri, Omid Zamani, Ricard Cervera, Daniel J. Wallace, Dana Tegzová, Jorge Sanchez-Guerrero, Andreas Schwarting, Joan T. Merrill, W. Winn Chatham, William Stohl, Ellen M. Ginzler, Douglas R. Hough, Z. John Zhong, William Freimuth and Ronald F. van Vollenhoven, BLISS-76 Study Group

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30613

    2. B lymphocyte stimulator levels in systemic lupus erythematosus: Higher circulating levels in African American patients and increased production after influenza vaccination in patients with low baseline levels (pages 3931–3941)

      Lauren L. Ritterhouse, Sherry R. Crowe, Timothy B. Niewold, Joan T. Merrill, Virginia C. Roberts, Amy B. Dedeke, Barbara R. Neas, Linda F. Thompson, Joel M. Guthridge and Judith A. James

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30598

    3. Dual effect of the macrophage migration inhibitory factor gene on the development and severity of human systemic lupus erythematosus (pages 3942–3951)

      Antoine Sreih, Rana Ezzeddine, Lin Leng, Avery LaChance, Geraldine Yu, Yuka Mizue, Lakshman Subrahmanyan, Bernardo A. Pons-Estel, Anna-Karin Abelson, Iva Gunnarsson, Elisabet Svenungsson, Joshua Cavett, Stuart Glenn, Lin Zhang, Ruth Montgomery, Andras Perl, Jane Salmon, Marta E. Alarcón-Riquelme, John B. Harley and Richard Bucala

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30624

    4. NR2-reactive antibody decreases cell viability through augmentation of Ca2+ influx in systemic lupus erythematosus (pages 3952–3959)

      Takahisa Gono, Takeshi Takarada, Ryo Fukumori, Yasushi Kawaguchi, Hirotaka Kaneko, Masanori Hanaoka, Yasuhiro Katsumata, Yukio Yoneda and Hisashi Yamanaka

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30616

  14. Antiphospholipid Syndrome

    1. Top of page
    2. In This Issue
    3. Special Article
    4. Commentary
    5. Editorials
    6. Rheumatoid Arthritis
    7. Spondylarthritis
    8. Experimental Arthritis
    9. Osteoarthritis
    10. Clinical Images
    11. Cartilage and Disc Biology
    12. Clinical Images
    13. Bone Biology
    14. Systemic Lupus Erythematosus
    15. Antiphospholipid Syndrome
    16. Systemic Sclerosis
    17. Vasculitis
    18. Gout
    19. Autoinflammatory Disease
    20. Radiology
    21. Erratum
    22. Concise Communication
    23. Letters
    24. Late-Breaking Abstracts
    25. Reviewers
    26. Contents, Volume 63, 2011
    27. ACR Announcements
    1. Immune responses against domain I of β2-glycoprotein I are driven by conformational changes: Domain I of β2-glycoprotein I harbors a cryptic immunogenic epitope (pages 3960–3968)

      Bas de Laat, Miranda van Berkel, Rolf T. Urbanus, Berdien Siregar, Philip G. de Groot, Martijn F. Gebbink and Coen Maas

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30633

  15. Systemic Sclerosis

    1. Top of page
    2. In This Issue
    3. Special Article
    4. Commentary
    5. Editorials
    6. Rheumatoid Arthritis
    7. Spondylarthritis
    8. Experimental Arthritis
    9. Osteoarthritis
    10. Clinical Images
    11. Cartilage and Disc Biology
    12. Clinical Images
    13. Bone Biology
    14. Systemic Lupus Erythematosus
    15. Antiphospholipid Syndrome
    16. Systemic Sclerosis
    17. Vasculitis
    18. Gout
    19. Autoinflammatory Disease
    20. Radiology
    21. Erratum
    22. Concise Communication
    23. Letters
    24. Late-Breaking Abstracts
    25. Reviewers
    26. Contents, Volume 63, 2011
    27. ACR Announcements
    1. Left ventricular dysfunction assessed by speckle-tracking strain analysis in patients with systemic sclerosis: Relationship to functional capacity and ventricular arrhythmias (pages 3969–3978)

      Kai Hang Yiu, Anne A. Schouffoer, Nina Ajmone Marsan, Maarten K. Ninaber, Jan Stolk, Thea Vliet Vlieland, Roderick W. Scherptong, Victoria Delgado, Eduard R. Holman, Hung Fat Tse, Tom W. J. Huizinga, Jeroen J. Bax and Annemie J. M. Schuerwegh

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30614

    2. Evidence of the contribution of the X chromosome to systemic sclerosis susceptibility: Association with the functional IRAK1 196Phe/532Ser haplotype (pages 3979–3987)

      P. Dieudé, M. Bouaziz, M. Guedj, G. Riemekasten, P. Airò, M. Müller, D. Cusi, M. Matucci-Cerinic, I. Melchers, W. Koenig, E. Salvi, H. E. Wichmann, G. Cuomo, E. Hachulla, E. Diot, N. Hunzelmann, P. Caramaschi, L. Mouthon, V. Riccieri, J. Distler, I. Tarner, J. Avouac, O. Meyer, A. Kahan, G. Chiocchia, C. Boileau and Y. Allanore

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30640

  16. Vasculitis

    1. Top of page
    2. In This Issue
    3. Special Article
    4. Commentary
    5. Editorials
    6. Rheumatoid Arthritis
    7. Spondylarthritis
    8. Experimental Arthritis
    9. Osteoarthritis
    10. Clinical Images
    11. Cartilage and Disc Biology
    12. Clinical Images
    13. Bone Biology
    14. Systemic Lupus Erythematosus
    15. Antiphospholipid Syndrome
    16. Systemic Sclerosis
    17. Vasculitis
    18. Gout
    19. Autoinflammatory Disease
    20. Radiology
    21. Erratum
    22. Concise Communication
    23. Letters
    24. Late-Breaking Abstracts
    25. Reviewers
    26. Contents, Volume 63, 2011
    27. ACR Announcements
    1. Circulating markers of vascular injury and angiogenesis in antineutrophil cytoplasmic antibody–associated vasculitis (pages 3988–3997)

      Paul A. Monach, Gunnar Tomasson, Ulrich Specks, John H. Stone, David Cuthbertson, Jeffrey Krischer, Linna Ding, Fernando C. Fervenza, Barri J. Fessler, Gary S. Hoffman, David Ikle, Cees G. M. Kallenberg, Carol A. Langford, Mark Mueller, Philip Seo, E. William St.Clair, Robert Spiera, Nadia Tchao, Steven R. Ytterberg, Yi-Zhong Gu, Ronald D. Snyder and Peter A. Merkel

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30615

    2. Purpura, cutaneous necrosis, and antineutrophil cytoplasmic antibodies associated with levamisole-adulterated cocaine (pages 3998–4001)

      Jonathan Graf, Kara Lynch, Chia-Lin Yeh, Laura Tarter, Nicole Richman, Thuy Nguyen, Alex Kral, Steven Dominy and John Imboden

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30590

  17. Gout

    1. Top of page
    2. In This Issue
    3. Special Article
    4. Commentary
    5. Editorials
    6. Rheumatoid Arthritis
    7. Spondylarthritis
    8. Experimental Arthritis
    9. Osteoarthritis
    10. Clinical Images
    11. Cartilage and Disc Biology
    12. Clinical Images
    13. Bone Biology
    14. Systemic Lupus Erythematosus
    15. Antiphospholipid Syndrome
    16. Systemic Sclerosis
    17. Vasculitis
    18. Gout
    19. Autoinflammatory Disease
    20. Radiology
    21. Erratum
    22. Concise Communication
    23. Letters
    24. Late-Breaking Abstracts
    25. Reviewers
    26. Contents, Volume 63, 2011
    27. ACR Announcements
    1. A two-stage approach to the treatment of hyperuricemia in gout: The “dirty dish” hypothesis (pages 4002–4006)

      Fernando Perez-Ruiz, Ana Maria Herrero-Beites and Loreto Carmona

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30649

  18. Autoinflammatory Disease

    1. Top of page
    2. In This Issue
    3. Special Article
    4. Commentary
    5. Editorials
    6. Rheumatoid Arthritis
    7. Spondylarthritis
    8. Experimental Arthritis
    9. Osteoarthritis
    10. Clinical Images
    11. Cartilage and Disc Biology
    12. Clinical Images
    13. Bone Biology
    14. Systemic Lupus Erythematosus
    15. Antiphospholipid Syndrome
    16. Systemic Sclerosis
    17. Vasculitis
    18. Gout
    19. Autoinflammatory Disease
    20. Radiology
    21. Erratum
    22. Concise Communication
    23. Letters
    24. Late-Breaking Abstracts
    25. Reviewers
    26. Contents, Volume 63, 2011
    27. ACR Announcements
    1. A novel mutation of IL1RN in the deficiency of interleukin-1 receptor antagonist syndrome: Description of two unrelated cases from Brazil (pages 4007–4017)

      Adriana A. Jesus, Mazen Osman, Clovis A. Silva, Peter W. Kim, Tuyet-Hang Pham, Massimo Gadina, Barbara Yang, Débora R. Bertola, Magda Carneiro-Sampaio, Polly J. Ferguson, Blair R. Renshaw, Ken Schooley, Michael Brown, Asma Al-Dosari, Jamil Al-Alami, John E. Sims, Raphaela Goldbach-Mansky and Hatem El-Shanti

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30588

    2. The first reported case of compound heterozygous IL1RN mutations causing deficiency of the interleukin-1 receptor antagonist (pages 4018–4022)

      Matthew Stenerson, Kevin Dufendach, Ivona Aksentijevich, Jillian Brady, Jared Austin and Ann M. Reed

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30565

  19. Radiology

    1. Top of page
    2. In This Issue
    3. Special Article
    4. Commentary
    5. Editorials
    6. Rheumatoid Arthritis
    7. Spondylarthritis
    8. Experimental Arthritis
    9. Osteoarthritis
    10. Clinical Images
    11. Cartilage and Disc Biology
    12. Clinical Images
    13. Bone Biology
    14. Systemic Lupus Erythematosus
    15. Antiphospholipid Syndrome
    16. Systemic Sclerosis
    17. Vasculitis
    18. Gout
    19. Autoinflammatory Disease
    20. Radiology
    21. Erratum
    22. Concise Communication
    23. Letters
    24. Late-Breaking Abstracts
    25. Reviewers
    26. Contents, Volume 63, 2011
    27. ACR Announcements
    1. Association between cam-type deformities and magnetic resonance imaging–detected structural hip damage: A cross-sectional study in young men (pages 4023–4030)

      Stephan Reichenbach, Michael Leunig, Stefan Werlen, Eveline Nüesch, Christian W. Pfirrmann, Harald Bonel, Alex Odermatt, Willy Hofstetter, Reinhold Ganz and Peter Jüni

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30589

  20. Erratum

    1. Top of page
    2. In This Issue
    3. Special Article
    4. Commentary
    5. Editorials
    6. Rheumatoid Arthritis
    7. Spondylarthritis
    8. Experimental Arthritis
    9. Osteoarthritis
    10. Clinical Images
    11. Cartilage and Disc Biology
    12. Clinical Images
    13. Bone Biology
    14. Systemic Lupus Erythematosus
    15. Antiphospholipid Syndrome
    16. Systemic Sclerosis
    17. Vasculitis
    18. Gout
    19. Autoinflammatory Disease
    20. Radiology
    21. Erratum
    22. Concise Communication
    23. Letters
    24. Late-Breaking Abstracts
    25. Reviewers
    26. Contents, Volume 63, 2011
    27. ACR Announcements
    1. You have free access to this content
      Erratum: Prediction of pulmonary hypertension related to systemic sclerosis by an index based on simple clinical observations (page 4030)

      Christophe Meune, Jérôme Avouac, Paolo Airò, Lorenzo Beretta, Philippe Dieudé, Karim Wahbi, Paola Caramaschi, Kiet Tiev, Susanna Cappelli, Elisabeth Diot, Alessandra Vacca, Jean-Luc Cracowski, Jean Sibilia, André Kahan, Marco Matucci-Cerinic and Yannick Allanore

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.33473

  21. Concise Communication

    1. Top of page
    2. In This Issue
    3. Special Article
    4. Commentary
    5. Editorials
    6. Rheumatoid Arthritis
    7. Spondylarthritis
    8. Experimental Arthritis
    9. Osteoarthritis
    10. Clinical Images
    11. Cartilage and Disc Biology
    12. Clinical Images
    13. Bone Biology
    14. Systemic Lupus Erythematosus
    15. Antiphospholipid Syndrome
    16. Systemic Sclerosis
    17. Vasculitis
    18. Gout
    19. Autoinflammatory Disease
    20. Radiology
    21. Erratum
    22. Concise Communication
    23. Letters
    24. Late-Breaking Abstracts
    25. Reviewers
    26. Contents, Volume 63, 2011
    27. ACR Announcements
    1. Treatment of pediatric Erdheim-Chester disease with interleukin-1–targeting drugs (pages 4031–4032)

      T. A. Tran, D. Pariente, J. C. Lecron, A. Delwail, Y. Taoufik and U. Meinzer

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30638

  22. Letters

    1. Top of page
    2. In This Issue
    3. Special Article
    4. Commentary
    5. Editorials
    6. Rheumatoid Arthritis
    7. Spondylarthritis
    8. Experimental Arthritis
    9. Osteoarthritis
    10. Clinical Images
    11. Cartilage and Disc Biology
    12. Clinical Images
    13. Bone Biology
    14. Systemic Lupus Erythematosus
    15. Antiphospholipid Syndrome
    16. Systemic Sclerosis
    17. Vasculitis
    18. Gout
    19. Autoinflammatory Disease
    20. Radiology
    21. Erratum
    22. Concise Communication
    23. Letters
    24. Late-Breaking Abstracts
    25. Reviewers
    26. Contents, Volume 63, 2011
    27. ACR Announcements
    1. Rheumatoid arthritis subgroup with type I interferon signature: Comment on the article by Thurlings et al (page 4033)

      Jin Kyun Park

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30609

    2. Reply (pages 4033–4034)

      Paul P. Tak

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30608

    3. Immunoglobulin free light chain levels and rituximab response in rheumatoid arthritis: Comment on the article by Sellam et al (pages 4034–4035)

      Janneke Tekstra, Joel van Roon, Tom Groot Kormelink and Frank Redegeld

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30632

    4. Reply (page 4035)

      Jérémie Sellam, Yassine Taoufik, Maxime Dougados and Xavier Mariette

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30631

    5. Recognizing the dense fine speckled/lens epithelium–derived growth factor/p75 pattern on HEp-2 cells: Not an easy task! Comment on the article by Mariz et al (pages 4036–4037)

      Nicola Bizzaro, Elio Tonutti and Danilo Villalta

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30621

    6. Reply (pages 4037–4038)

      Alessandra Dellavance, Henrique de Ataíde Mariz, Emilia Inoue Sato and Luis Eduardo Coelho Andrade

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30618

    7. Further questions remain concerning osteoarthritis risk and index finger–to–ring finger length ratios: Comment on the article by Haugen et al (page 4038)

      F. A. Vijfvinkel, D. Schiphof and A. P. Verhagen

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30597

    8. Reply (pages 4038–4039)

      Ida K. Haugen and Martin Englund

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30601

    9. Need for international consensus on examining for joint laxity: Comment on the article by Clinch et al (pages 4039–4040)

      Lars Remvig and Birgit Juul-Kristensen

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30620

    10. Reply (page 4040)

      Jacqui Clinch

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.30619

  23. Late-Breaking Abstracts

    1. Top of page
    2. In This Issue
    3. Special Article
    4. Commentary
    5. Editorials
    6. Rheumatoid Arthritis
    7. Spondylarthritis
    8. Experimental Arthritis
    9. Osteoarthritis
    10. Clinical Images
    11. Cartilage and Disc Biology
    12. Clinical Images
    13. Bone Biology
    14. Systemic Lupus Erythematosus
    15. Antiphospholipid Syndrome
    16. Systemic Sclerosis
    17. Vasculitis
    18. Gout
    19. Autoinflammatory Disease
    20. Radiology
    21. Erratum
    22. Concise Communication
    23. Letters
    24. Late-Breaking Abstracts
    25. Reviewers
    26. Contents, Volume 63, 2011
    27. ACR Announcements
    1. 2011 ACR/ARHP Annual Scientific Meeting Late-Breaking Abstracts (pages 4041–4047)

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.33477

  24. Reviewers

    1. Top of page
    2. In This Issue
    3. Special Article
    4. Commentary
    5. Editorials
    6. Rheumatoid Arthritis
    7. Spondylarthritis
    8. Experimental Arthritis
    9. Osteoarthritis
    10. Clinical Images
    11. Cartilage and Disc Biology
    12. Clinical Images
    13. Bone Biology
    14. Systemic Lupus Erythematosus
    15. Antiphospholipid Syndrome
    16. Systemic Sclerosis
    17. Vasculitis
    18. Gout
    19. Autoinflammatory Disease
    20. Radiology
    21. Erratum
    22. Concise Communication
    23. Letters
    24. Late-Breaking Abstracts
    25. Reviewers
    26. Contents, Volume 63, 2011
    27. ACR Announcements
    1. Reviewers (pages 4048–4054)

      Joan M. Bathon

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.33499

  25. Contents, Volume 63, 2011

    1. Top of page
    2. In This Issue
    3. Special Article
    4. Commentary
    5. Editorials
    6. Rheumatoid Arthritis
    7. Spondylarthritis
    8. Experimental Arthritis
    9. Osteoarthritis
    10. Clinical Images
    11. Cartilage and Disc Biology
    12. Clinical Images
    13. Bone Biology
    14. Systemic Lupus Erythematosus
    15. Antiphospholipid Syndrome
    16. Systemic Sclerosis
    17. Vasculitis
    18. Gout
    19. Autoinflammatory Disease
    20. Radiology
    21. Erratum
    22. Concise Communication
    23. Letters
    24. Late-Breaking Abstracts
    25. Reviewers
    26. Contents, Volume 63, 2011
    27. ACR Announcements
    1. Volume 63 Table of Contents (pages 4055–4094)

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.33500

  26. ACR Announcements

    1. Top of page
    2. In This Issue
    3. Special Article
    4. Commentary
    5. Editorials
    6. Rheumatoid Arthritis
    7. Spondylarthritis
    8. Experimental Arthritis
    9. Osteoarthritis
    10. Clinical Images
    11. Cartilage and Disc Biology
    12. Clinical Images
    13. Bone Biology
    14. Systemic Lupus Erythematosus
    15. Antiphospholipid Syndrome
    16. Systemic Sclerosis
    17. Vasculitis
    18. Gout
    19. Autoinflammatory Disease
    20. Radiology
    21. Erratum
    22. Concise Communication
    23. Letters
    24. Late-Breaking Abstracts
    25. Reviewers
    26. Contents, Volume 63, 2011
    27. ACR Announcements
    1. ACR announcements

      Article first published online: 29 NOV 2011 | DOI: 10.1002/art.33438

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