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Role of initial NSAID choice and patient risk factors in the prevention of NSAID gastropathy: A decision analysis
Article first published online: 7 FEB 2002
DOI: 10.1002/art1.10159
Copyright © 2002 by the American College of Rheumatology
Additional Information
How to Cite
Fendrick, A. M., Bandekar, R. R., Chernew, M. E. and Scheiman, J. M. (2002), Role of initial NSAID choice and patient risk factors in the prevention of NSAID gastropathy: A decision analysis. Arthritis & Rheumatism, 47: 36–43. doi: 10.1002/art1.10159
Publication History
- Issue published online: 7 FEB 2002
- Article first published online: 7 FEB 2002
- Manuscript Accepted: 1 JUL 2001
- Manuscript Received: 5 APR 2001
Funded by
- SmithKline Beecham
REFERENCES
- 1, , . Risk for serious gastrointestinal complications related to use of NSAIDS: a meta-analysis Ann Intern Med 1991; 115: 787–96.
- 2, , . Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs N Engl J Med 1999; 340: 1888–99.
- 3, , , . Excess costs from gastrointestinal disease associated with nonsteroidal anti-inflammatory drugs J Gen Intern Med 1996; 11: 461–9.
- 4
- 5. Public misunderstanding of nonsteroidal antiinflammatory drug (NSAID)-mediated gastrointestinal complications toxicity: a serious potential health threat Gastroenterology 1998; 114: G0555.
- 6
- 7, , , , , , et al. Gastrointestinal toxicity with celecoxib vs. nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis. The class study: a randomized controlled trial JAMA 2000; 284: 1247–55.
- 8, , , , , , et al. Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis N Engl J Med 2000; 343: 1505–84.
- 9. Preventing NSAID-induced gastrointestinal toxicity. Economic considerations, methodological problems and results Pharmacoeconomics 1995; 7: 99–110.
- 10, , , . Economics evaluation of gastric ulcer prophylaxis in patients with arthritis receiving non-steroidal anti-inflammatory drugs Postgrad Med J 1990; 66: 639–46.
- 11, , . The cost effectiveness of diclofenac plus misoprostol compared with diclofenac monotherapy in patients with rheumatoid arthritis Pharmacoeconomics 1996; 10: 141–51.
- 12, , . The cost-effectiveness of misoprostol in preventing serious gastrointestinal events associated with the use of nonsteroidal antiinflammatory drugs Arthritis Rheum 1998; 41: 16–25.Direct Link:
- 13. Misoprostol for the treatment of peptic ulcer and antiinflammatory drug induced gastroduodenal ulceration N Engl J Med 1992; 327: 1575–80.
- 14, , , , . Analysis of the costs of NSAID-associated gastropathy. Experience in a US health maintenance organization Pharmacoeconomics 1997; 12: 76–88.
- 15, . Nonsteroidal anti-inflammatory drugs, Helicobacter pylori, and ulcers: where we stand Am J Gastroenterol 1996; 91: 2080–6.
- 16, Multicenter Group. Treatment of endoscopy negative NSAID-induced upper gastrointestinal symptoms with cimetidine: an international multicenter collaborative study Aliment Pharmacol Ther 1988; 2S: 75.
- 17, , , . Prevention of nonsteroidal anti-inflammatory drug-induced gastrointestinal mucosal injury. A meta-analysis of randomized controlled clinical trials Arch Intern Med 1996; 156: 2321–32.
- 18, , , , , , et al. Famotidine for the prevention of gastric and duodenal ulcers caused by nonsteroidal anti-inflammatory drugs N Engl J Med 1996; 334: 1435–9.
- 19, , , , , , et al. Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs N Engl J Med 1998; 338: 727–34.
- 20, , , , , , et al. Primary gastroduodenal prophylaxis with omeprazole for NSAID users Aliment Pharmacol Ther 1998; 12: 135–40.Direct Link:
- 21, , , , , , et al. Omeprazole reduces the frequency of gastroduodenal lesions and dyspeptic symptoms during NSAID treatment Scand J Gastroenterol 1996; 31: 753–8.
- 22, , , , , , et al. Inducible isoforms of cyclooxygenase and nitric oxide synthase in inflammation Proc Natl Acad Sci U S A 1994; 91: 2046–50.
- 23, . NSAIDs, cytoprotection, and gastrointestinal injury Gastroenterol Clin North Am 1996; 25: 279–98.
- 24, . Markov models in medical decision making: a practical guide Med Decis Making 1993; 13: 322–38.
- 25, . Non-steroidal anti-inflammatory drugs and life threatening complications of peptic ulceration Gut 1987; 28: 527–32.
- 26, , , , . Dyspepsia in NSAID users: the size of the problem J Clin Gastroenterol 1989; 11: 158–62.
- 27, , . Decision analytic modeling and NSAID gastropathy: could we be more sensitive? J Gen Intern Med 2000; 15: 430–1.Direct Link:
- 28, , , , , , et al. A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs. N Engl J Med 1998; 338: 719–26.
- 29, , . Prevention of NSAID-induced gastric ulcer with misoprostol: multicenter, double-blind, placebo-controlled trial. Lancet 1988; ii: 1277–80.
- 30, , , , , , et al. Effect of omeprazole and ranitidine on ulcer healing and relapse rates in patients with benign gastric ulcer. N Engl J Med 1989; 320: 69–75.
- 31, , . Misoprostol dosage in the prevention of nonsteroidal anti-inflammatory drug-induced gastric and duodenal ulcers: a comparison of three regimens. Ann Intern Med 1995; 123: 344–50.
- 32, , , , , . Misoprostol and ranitidine in the prevention of NSAID-induced ulcers: a prospective, double blind, multicenter study. Am J Gastroenterol 1996; 91: 223–7.
- 33, , , . Prevention of gastroduodenal damage induced by non-steroidal anti-inflammatory drugs: controlled trial of ranitidine. BMJ 1988; 297: 1017–21.
- 34, , , , , , et al. Effect of ranitidine on gastroduodenal mucosal damage induced by nonsteroidal anti-inflammatory drugs. Dig Dis Sci 1989; 34: 424–8.
- 35, , . Nizatidine prevents peptic ulceration in high-risk patients taking nonsteroidal anti-inflammatory drugs. Arch Intern Med 1993; 153: 2449–54.
- 36, , , , , , et al. Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs. A randomized double-blind, placebo controlled trial. Ann Intern Med 1995; 123: 241–9.
- 37, , , , , , et al. A controlled study comparing the effects of nabumetone, ibuprofen, and ibuprofen plus misoprostol on the upper gastrointestinal mucosa. Arch Intern Med 1993; 153: 2565–71.
- 38
- 39, . Do cyclooxygenase-2 inhibitors provide benefits similar to those of traditional nonsteroidal anti-inflammatory drugs, with less gastrointestinal toxicity? Ann Intern Med 2000; 132: 134–43.
- 40, , , , . Stratifying the risk of clinical upper GI events in NSAID users: results from a double-blind outcomes study [abstract]. Gastroenterology 2001; 120: A105.
- 41, . COX-1 sparing NSAIDs: is the enthusiasm justified? JAMA 2000; 282: 1961–3.

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