This article describes the emerging role of educational multiuser virtual environments, specifically Second Life™, in anatomical sciences education. Virtual worlds promote inquiry-based learning and conceptual understanding, potentially making them applicable for teaching and learning gross anatomy. A short introduction to Second Life as an anatomical educational tool is provided, along with description of existing anatomy applications and future directions for this innovative teaching modality. Anat Sci Educ. © 2011 American Association of Anatomists.