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Keywords:

  • antitumor agents;
  • automated synthesis;
  • natural products;
  • synthetic methods;
  • total synthesis

Abstract

A 36-step synthesis was carried out in automated synthesizers to provide a synthetic key intermediate of taxol. A key step involved a microwave-assisted alkylation reaction to construct the ABC ring system from an AC precursor. Subsequent formation of the D ring afforded baccatin III, a well-known precursor of taxol.