1861-471X/asset/2451_left.gif?v=1&s=879804fa8b46cf0a7c9ada963b3a3d8b5e4c5a21)
1861-471X/asset/olbannercenter.gif?v=1&s=168589aa4ee06245869d9ebf5e050019ec1c9da7)
1861-471X/asset/2451_right.gif?v=1&s=7e39970753c72792f9c3045b7c65df3b29c1b6a0)
Focus Review
Enantioselective Tsuji Allylations
Article first published online: 12 OCT 2007
DOI: 10.1002/asia.200700183
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Mohr, Justin T. and Stoltz, Brian M. (2007), Enantioselective Tsuji Allylations. Chem. Asian J., 2: 1476–1491. doi: 10.1002/asia.200700183
Publication History
- Issue published online: 27 NOV 2007
- Article first published online: 12 OCT 2007
- Manuscript Received: 31 MAY 2007
Funded by
- NIH-NIGMS. Grant Number: R01 GM 080269-01
- Eli Lilly
- Caltech
- Abstract
- Article
- References
- Cited By
Keywords:
- allylation;
- asymmetric catalysis;
- enols;
- ketones;
- palladium
Abstract
The family of allylation reactions developed by Tsuji in the 1980s are capable of generating tertiary and quaternary carbon stereocenters from several synthetic precursors. Despite the utility of these transformations, they have seen little use in the synthesis of natural products. Recently, the power of these reactions was significantly enhanced by the development of enantioselective versions of these transformations. Applications of these methods to the enantioselective syntheses of natural products and pharmaceutical compounds highlight the importance of these developments.