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A Supported Rhodium Hydroxide Catalyst: Preparation, Characterization, and Scope of the Synthesis of Primary Amides from Aldoximes or Aldehydes

Authors

  • Hiroshi Fujiwara,

    1. Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan), Fax: (+81) 3-5841-7220
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  • Yoshiyuki Ogasawara,

    1. Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan), Fax: (+81) 3-5841-7220
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  • Miyuki Kotani,

    1. Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012 (Japan)
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  • Kazuya Yamaguchi Dr.,

    1. Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan), Fax: (+81) 3-5841-7220
    2. Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012 (Japan)
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  • Noritaka Mizuno Prof. Dr.

    1. Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan), Fax: (+81) 3-5841-7220
    2. Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012 (Japan)
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Abstract

A supported rhodium hydroxide catalyst, Rh(OH)x/Al2O3 (x=3), is prepared by the reaction of Al2O3 with RhCl3 in an aqueous medium followed by treatment with NaOH. The RhIII hydroxide species is monomerically (or highly) dispersed on the Al2O3 support. Rh(OH)x/Al2O3 acts as a reusable heterogeneous catalyst in water, rather than in an explosive, hazardous, and carcinogenic organic solvent, for the synthesis of primary amides from aldoximes or aldehydes by an efficient sequential process of dehydration and rehydration. The dehydrative condensation of aldehydes and hydroxylamine is also promoted by the Rh(OH)x/Al2O3 catalyst.

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