Flower-Like Hierarchically Nanostructured Hydroxyapatite Hollow Spheres: Facile Preparation and Application in Anticancer Drug Cellular Delivery

Authors

  • Ke-Wei Wang,

    1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 (P.R. China), Fax: (+86) 21-52413122
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  • Prof. Dr. Ying-Jie Zhu,

    Corresponding author
    1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 (P.R. China), Fax: (+86) 21-52413122
    • Ying-Jie Zhu, State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 (P.R. China), Fax: (+86) 21-52413122

      You-Rong Duan, Cancer Institute of Shanghai Jiao Tong University, Shanghai, 200032 (P.R. China)

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  • Xiao-Yan Chen,

    1. Cancer Institute of Shanghai Jiao Tong University, Shanghai, 200032 (P.R. China)
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  • Wan-Yin Zhai,

    1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 (P.R. China), Fax: (+86) 21-52413122
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  • Qi Wang,

    1. Cancer Institute of Shanghai Jiao Tong University, Shanghai, 200032 (P.R. China)
    2. Key Laboratory of Drug Targeting of Ministry of Education, School of Pharmacy, Sichuan University, Chengdu, 610041 (P.R. China)
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  • Feng Chen,

    1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 (P.R. China), Fax: (+86) 21-52413122
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  • Prof. Dr. Jiang Chang,

    1. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 (P.R. China), Fax: (+86) 21-52413122
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  • Prof. Dr. You-Rong Duan

    Corresponding author
    1. Cancer Institute of Shanghai Jiao Tong University, Shanghai, 200032 (P.R. China)
    • Ying-Jie Zhu, State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 (P.R. China), Fax: (+86) 21-52413122

      You-Rong Duan, Cancer Institute of Shanghai Jiao Tong University, Shanghai, 200032 (P.R. China)

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Abstract

Flower-like nanostructured hydroxyapatite hollow spheres (NHHS) assembled with nanosheets with a hierarchical morphology are fabricated by a rapid microwave-assisted hydrothermal route. The presence and concentration of block copolymer poly(lactide)-block-poly(ethylene glycol) (PLA–PEG) are important parameters for the formation of the hollow structure. The possible formation mechanism of NHHS is proposed. The NHHS are explored as anticancer drug carriers for cellular delivery of mitoxantrone (MIT). The MIT-loaded NHHS exhibit sustained-drug-release behavior in vitro and the intracellular drug-distribution tests indicate that the MIT loaded in NHHS carriers can enter the cells efficiently. The experiments also show that the NHHS have a good biocompatibility, and therefore, they are promising anticancer drug carriers in cancer chemotherapy.

Abstract

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