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Keywords:

  • liposomes;
  • microreactors;
  • pyrophosphate;
  • sensors;
  • zinc

Abstract

A microarray-chip assay system for the fluorescence detection of phosphate-containing analytes in aqueous media has been constructed from stimuli-responsive polymerized poly(diacetylene)-liposomes for the first time. Proper combination of the liposome components (ZnII-dipicolylamine for phosphate binding and an amine-terminated component for anchoring the liposome onto an aldehyde-derivatized glass plate), has led to a microarray chip that selectively detects pyrophosphate, an important biomarker, over competing anions, such as phosphate and adenosine triphosphate, with nanomolar sensitivity. The chip-based assay shows advantages, such as high specificity and sensitivity, over solution-based assays that use the same liposomes, and over known homogeneous molecular sensing systems.

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Featured Compounds

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Compound 2
Molecular Weight:684.0085
Molecular Formula:C43H65N5O2
InChIKey:Not Available
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Compound 1
Molecular Weight:416.6828
Molecular Formula:C27H48N2O
InChIKey:Not Available
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Compound 3
Molecular Weight:1076.6699
Molecular Formula:Not Available
InChIKey:Not Available
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Compound 4
Molecular Weight:1142.079
Molecular Formula:Not Available
InChIKey:Not Available
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Compound 5
Molecular Weight:1143.064
Molecular Formula:Not Available
InChIKey:Not Available
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