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Keywords:

  • click chemistry;
  • doxorubicin;
  • drug delivery;
  • enzymes;
  • intracellular imaging

Abstract

Enzyme-responsive, hybrid, magnetic silica nanoparticles have been employed for multifunctional applications in selective drug delivery and intracellular tumor imaging. In this study, doxorubicin (Dox)-conjugated, enzyme-cleavable peptide precursors were covalently tethered onto the surface of uniform silica-coated magnetic nanoparticles through click chemistry. This enzyme-responsive nanoparticle conjugate demonstrated highly efficient Dox release upon specific enzyme interactions in vitro. It also exhibits multiple functions in selective tumor intracellular drug delivery and imaging in the tumor cells with high cathepsin B expression, whereas it exhibited lower cytotoxicity towards other cells without enzyme expression.

Featured Compounds

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  1. 1 - 9
Compound 1
Molecular Weight:484.5
Molecular Formula:C28H24N2O6
InChIKey:VLXHZQQUTCVLGU-UHFFFAOYSA-N
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Compound 2
Molecular Weight:402.5286
Molecular Formula:C26H30N2O2
InChIKey:URQNDMXCKJEUEW-UHFFFAOYSA-N
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Compound 3
Molecular Weight:771.9412
Molecular Formula:C50H49N3O5
InChIKey:FBZOAAKJRASHFT-UHFFFAOYSA-N
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Compound 4
Molecular Weight:877.0783
Molecular Formula:C57H56N4O5
InChIKey:AUQPJRULIZRUAY-UHFFFAOYSA-N
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Compound 5
Molecular Weight:655.8476
Molecular Formula:C42H46N4O3
InChIKey:MGTWXHPRRFYSKP-UHFFFAOYSA-O
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Compound 6
Molecular Weight:734.9243
Molecular Formula:C47H50N4O4
InChIKey:UOEINDSNXAQMFQ-UHFFFAOYSA-N
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Compound 7
Molecular Weight:900.0273
Molecular Formula:C54H53N5O8
InChIKey:AMCNNWQPRAAESI-UHFFFAOYSA-N
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Compound 8
Molecular Weight:1304.4377
Molecular Formula:C75H77N5O16
InChIKey:VZLGNJYDBRLTFQ-UHFFFAOYSA-N
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Compound 9
Molecular Weight:1049.1047
Molecular Formula:C55H61N5O16
InChIKey:GDBYHXLNHRDNFM-UHFFFAOYSA-O
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  1. 1 - 9