[Cu(acac)2]⋅H2O-Catalyzed Sonogashira-Type Couplings of Aryl Halides and Terminal Alkynes

Authors

  • Tingyi Li,

    1. Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123 (P. R. China), Fax: (+86) 512-6588-0403
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  • Xiaoming Qu,

    1. Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123 (P. R. China), Fax: (+86) 512-6588-0403
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  • Guanlei Xie,

    1. Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123 (P. R. China), Fax: (+86) 512-6588-0403
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  • Prof. Jincheng Mao

    Corresponding author
    1. Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123 (P. R. China), Fax: (+86) 512-6588-0403
    • Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123 (P. R. China), Fax: (+86) 512-6588-0403

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Abstract

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Highly selective coupling of aryl halides with terminal alkynes can be conducted using low-cost and readily available [Cu(acac)2]H2O under palladium- and amine-free conditions. This protocol makes the typical Sonogashira reaction more practical and useful (TBAB=tetrabutyl ammonium bromide; DMSO=dimethyl sulfoxide; see scheme).

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