A BODIPY-Based Probe for the Selective Detection of Hypochlorous Acid in Living Cells

Authors

  • Tae-Il Kim,

    1. Department of Chemistry, Dankook University, 126 Jukjeon-dong, Yongin-si, Gyeonggi-do 448-701 (Korea), Fax: (+82) 31-8005-3148
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    • These authors contributed equally to this work.

  • Seonhwa Park,

    1. Molecular Imaging & Therapy Branch, National Cancer Center, 323 Ilsan-ro, Goyang-si, Gyeonggi-do 410-769 (Korea)
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    • These authors contributed equally to this work.

  • Dr. Yongdoo Choi,

    Corresponding author
    1. Molecular Imaging & Therapy Branch, National Cancer Center, 323 Ilsan-ro, Goyang-si, Gyeonggi-do 410-769 (Korea)
    • Yongdoo Choi, Molecular Imaging & Therapy Branch, National Cancer Center, 323 Ilsan-ro, Goyang-si, Gyeonggi-do 410-769 (Korea)

      Youngmi Kim, Department of Chemistry, Dankook University, 126 Jukjeon-dong, Yongin-si, Gyeonggi-do 448-701 (Korea), Fax: (+82) 31-8005-3148

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  • Prof. Youngmi Kim

    Corresponding author
    1. Department of Chemistry, Dankook University, 126 Jukjeon-dong, Yongin-si, Gyeonggi-do 448-701 (Korea), Fax: (+82) 31-8005-3148
    • Yongdoo Choi, Molecular Imaging & Therapy Branch, National Cancer Center, 323 Ilsan-ro, Goyang-si, Gyeonggi-do 410-769 (Korea)

      Youngmi Kim, Department of Chemistry, Dankook University, 126 Jukjeon-dong, Yongin-si, Gyeonggi-do 448-701 (Korea), Fax: (+82) 31-8005-3148

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Abstract

original image

Stress light up! Methyl thio-BODIPY detects hypochlorous acid on the basis of the selective oxidation of its methylthioether group into the corresponding sulfoxide by the analyte, resulting in a strong fluorescence turn-on signal.

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