A Photostable Near-Infrared Protein Labeling Dye for In Vivo Imaging

Authors

  • Animesh Samanta,

    1. Department of Chemistry & MedChem Program of Life Sciences Institute, National University of Singapore, 3 Science Drive 3, 117543 Singapore (Singapore), Fax: (+65) 67791691
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    • Both authors contributed equally to this work.

  • Dr. Marc Vendrell,

    1. Laboratory of Bioimaging Probe Development, Singapore Bioimaging Consortium, Agency of Science, Technology and Research (A*STAR), 11 Biopolis Way, #02-02 Helios Building, 138667 Singapore (Singapore)
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    • Both authors contributed equally to this work.

  • Dr. Seong-Wook Yun,

    1. Laboratory of Bioimaging Probe Development, Singapore Bioimaging Consortium, Agency of Science, Technology and Research (A*STAR), 11 Biopolis Way, #02-02 Helios Building, 138667 Singapore (Singapore)
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  • Zhenping Guan,

    1. Department of Chemistry, National University of Singapore, 3 Science Drive 3, 117543 Singapore (Singapore)
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  • Prof. Qing-Hua Xu,

    1. Department of Chemistry, National University of Singapore, 3 Science Drive 3, 117543 Singapore (Singapore)
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  • Prof. Young-Tae Chang

    Corresponding author
    1. Department of Chemistry & MedChem Program of Life Sciences Institute, National University of Singapore, 3 Science Drive 3, 117543 Singapore (Singapore), Fax: (+65) 67791691
    2. Laboratory of Bioimaging Probe Development, Singapore Bioimaging Consortium, Agency of Science, Technology and Research (A*STAR), 11 Biopolis Way, #02-02 Helios Building, 138667 Singapore (Singapore)
    • Department of Chemistry & MedChem Program of Life Sciences Institute, National University of Singapore, 3 Science Drive 3, 117543 Singapore (Singapore), Fax: (+65) 67791691

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Abstract

original image

A NIR death experience: A highly photostable NIR protein-labeling dye () that maintained excellent fluorescent properties after protein conjugation has been synthesized. Furthermore, the adequacy of the dye for NIR imaging was confirmed by showing that the recognition properties of a labeled anti-EGFR antibody remained unaffected.

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