Tuning the Efficiency of Dendritic Nanocarriers using Conformational Constraints

Authors

  • T. B. N. Satyanarayana,

    1. Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012 (India), Fax: (+91) 80-2360-0529
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  • Prof. Dr. Uday Maitra

    Corresponding author
    1. Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012 (India), Fax: (+91) 80-2360-0529
    • Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012 (India), Fax: (+91) 80-2360-0529

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Abstract

A series of deoxycholic and cholic acid-derived oligomers were synthesized and their ability to extract hydrophilic dye molecules of different structure, size, and functional groups into nonpolar media was studied. The structure of the dye and “dendritic effect” in the extraction process was examined using absorption spectroscopy and dynamic light scattering (DLS). The efficiency of structurally preorganized oligomers in the aggregation process was evaluated by 1-anilinonaphthalene-8-sulfonic acid (ANS) fluorescence studies. The possible formation of globular structures for higher-generation molecules was investigated by molecular modeling studies and the results were correlated with the anomaly observed in the extraction process with this molecule. The ability of these molecules for selective extraction of specific dyes from blended colors is also reported.

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