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Chemical Synthesis of the Englerins

Authors

  • Dr. Rebecca H. Pouwer,

    1. Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane Innovation Park, Don Young Road, Nathan Qld 4111 (Australia)
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  • Dr. Jean-Alexandre Richard,

    1. Organic Chemistry@Helios, Institute of Chemical and Engineering Sciences (ICES), Agency for Science, Technology and Research (A*STAR), 11 Biopolis Way, The Helios Block, #03-08, Singapore 138667 (Singapore)
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  • Dr. Chih-Chung Tseng,

    1. The Department of Applied Chemistry, National Chiao Tung University, Rm. 312, Science Building 2, Hsinchu City 30010 (Taiwan)
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  • Prof. Dr. David Y.-K. Chen

    Corresponding author
    1. Department of Chemistry, Seoul National University, Gwanak-1 Gwanak-ro, Gwanak-gu, Seoul 151-742 (South Korea)
    • Department of Chemistry, Seoul National University, Gwanak-1 Gwanak-ro, Gwanak-gu, Seoul 151-742 (South Korea)

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Abstract

In the long lasting battle against cancer, Nature sometimes gives a helping hand to researchers to find new drugs for the treatment of diseases and improvement of patients′ well-being. Englerin A has emerged as a promising anticancer candidate as well as being an exciting synthetic challenge for organic chemists. This focus review summarizes the total syntheses reported to date and the synthetic approaches toward analogues of this fascinating natural product.

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