• glucose;
  • gold;
  • nanoparticles;
  • sensors;
  • seed-mediated growth
Thumbnail image of graphical abstract

A common limitation of gold nanoparticle (Au NP)-based sensing in natural samples is that non-specific binding of biomolecules on the Au NP surface interferes in sensing systems and causes a reduction in the selectivity and sensitivity. To circumvent such a limitation, a recently developed hollow nanoreactor with a nanorattle structure, consisting of a porous silica nanoshell and an entrapped Au NP, was employed. As described in their Communication on page 36 ff., I. S. Lee et al. report that the catalytic Au growth inside the protected cavity, which is accompanied by an SPR enhancement, allows for the quantitative detection of H2O2 and glucose concentrations, even in the presence of the interfering BSA proteins.