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Keywords:

  • amides;
  • oxidation;
  • oxygen;
  • peptide coupling;
  • synthetic methods
Thumbnail image of graphical abstract

Breathe easy: Molecular oxygen is one of the most abundant, atom-efficient, and economical oxidants. An aerobic oxidative amide formation from aldehydes and amines is reported. The method uses a catalytic amount of Co(OAc)2 and N-hydroxysuccinimide as reaction promoters. It is applicable to chiral substrates without loss of their optical purity.

Featured Compounds

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  1. 1 - 38
Compound A
Molecular Weight:Not Available
Molecular Formula:Not Available
InChIKey:Not Available
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Compound C
Molecular Weight:Not Available
Molecular Formula:Not Available
InChIKey:Not Available
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Compound 1a
Molecular Weight:134.1751
Molecular Formula:C9H10O
InChIKey:YGCZTXZTJXYWCO-UHFFFAOYSA-N
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Compound 2
Molecular Weight:295.2894
Molecular Formula:C17H13NO4
InChIKey:JPQIUWUEOYWICT-UHFFFAOYSA-N
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Compound 3
Molecular Weight:247.2466
Molecular Formula:C13H13NO4
InChIKey:MKQSZJPOEKYNKX-UHFFFAOYSA-N
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Compound 4
Molecular Weight:150.1745
Molecular Formula:C9H10O2
InChIKey:XMIIGOLPHOKFCH-UHFFFAOYSA-N
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Compound 2a
Molecular Weight:237.2533
Molecular Formula:C15H11NO2
InChIKey:WITXFYCLPDFRNM-UHFFFAOYSA-N
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Compound 5b
Molecular Weight:239.3123
Molecular Formula:C16H17NO
InChIKey:FEOUTXCSJHUHLP-UHFFFAOYSA-N
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Compound 1b
Molecular Weight:106.1219
Molecular Formula:C7H6O
InChIKey:HUMNYLRZRPPJDN-UHFFFAOYSA-N
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Compound 5a
Molecular Weight:253.3389
Molecular Formula:C17H19NO
InChIKey:HIUONFHURKCCKW-UHFFFAOYSA-N
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Compound 5c
Molecular Weight:329.4348
Molecular Formula:C23H23NO
InChIKey:FYQAKKHLSUGGMM-UHFFFAOYSA-N
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Compound 5d
Molecular Weight:193.2423
Molecular Formula:C11H15NO2
InChIKey:ANVULNURROKXKS-UHFFFAOYSA-N
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Compound 5e
Molecular Weight:253.3389
Molecular Formula:C17H19NO
InChIKey:RCLOJLWVCROWJC-AWEZNQCLSA-N
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Compound 5f
Molecular Weight:247.3327
Molecular Formula:C15H21NO2
InChIKey:LMKZPDQPLGSCHX-HDJSIYSDSA-N
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Compound 5g
Molecular Weight:283.3648
Molecular Formula:C18H21NO2
InChIKey:BLALGNRYTGSCPD-KRWDZBQOSA-N
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Compound 5h
Molecular Weight:283.3648
Molecular Formula:C18H21NO2
InChIKey:BLALGNRYTGSCPD-QGZVFWFLSA-N
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Compound 5i
Molecular Weight:203.2802
Molecular Formula:C13H17NO
InChIKey:AJQCDEYAAFXBBP-UHFFFAOYSA-N
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Compound 5j
Molecular Weight:217.3068
Molecular Formula:C14H19NO
InChIKey:HOJGUDWNFKNCPF-UHFFFAOYSA-N
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Compound 5k
Molecular Weight:221.2524
Molecular Formula:C12H15NO3
InChIKey:AINBXHSUDDGAAY-UHFFFAOYSA-N
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Compound 5l
Molecular Weight:207.2689
Molecular Formula:C12H17NO2
InChIKey:JMYOMUUHDZORRS-SNVBAGLBSA-N
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Compound 5m
Molecular Weight:207.2689
Molecular Formula:C12H17NO2
InChIKey:JMYOMUUHDZORRS-JTQLQIEISA-N
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Compound 5n
Molecular Weight:235.322
Molecular Formula:C14H21NO2
InChIKey:IDPLFPQBIVJWPM-ZDUSSCGKSA-N
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Compound 5o
Molecular Weight:235.322
Molecular Formula:C14H21NO2
InChIKey:IDPLFPQBIVJWPM-CYBMUJFWSA-N
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Compound 1c
Molecular Weight:112.1696
Molecular Formula:C7H12O
InChIKey:Not Available
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Compound 1e
Molecular Weight:136.1479
Molecular Formula:C8H8O2
InChIKey:ZRSNZINYAWTAHE-UHFFFAOYSA-N
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Compound 1f
Molecular Weight:151.1195
Molecular Formula:C7H5NO3
InChIKey:BXRFQSNOROATLV-UHFFFAOYSA-N
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Compound 5p
Molecular Weight:225.2857
Molecular Formula:C15H15NO
InChIKey:DAVRGGJTJDTVQT-UHFFFAOYSA-N
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Compound 5q
Molecular Weight:231.3333
Molecular Formula:C15H21NO
InChIKey:GPUHUEHNYUSRPW-UHFFFAOYSA-N
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Compound 5r
Molecular Weight:205.2961
Molecular Formula:C13H19NO
InChIKey:WFCFPUJKBRCPGJ-UHFFFAOYSA-N
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Compound 5s
Molecular Weight:255.3117
Molecular Formula:C16H17NO2
InChIKey:WUIBKBDHYVOURV-UHFFFAOYSA-N
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Compound 5t
Molecular Weight:270.2833
Molecular Formula:C15H14N2O3
InChIKey:NPTZNBFQWMQHKP-UHFFFAOYSA-N
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Compound 1d
Molecular Weight:86.1323
Molecular Formula:C5H10O
InChIKey:Not Available
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Compound 6a
Molecular Weight:175.2255
Molecular Formula:C8H17NO3
InChIKey:PDAFIZPRSXHMCO-LURJTMIESA-N
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Compound 6b
Molecular Weight:175.2255
Molecular Formula:C8H17NO3
InChIKey:PDAFIZPRSXHMCO-ZCFIWIBFSA-N
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Compound 7a
Molecular Weight:173.2096
Molecular Formula:C8H15NO3
InChIKey:OEQRZPWMXXJEKU-LURJTMIESA-N
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Compound 7b
Molecular Weight:173.2096
Molecular Formula:C8H15NO3
InChIKey:OEQRZPWMXXJEKU-ZCFIWIBFSA-N
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Compound 8a
Molecular Weight:260.2869
Molecular Formula:C11H20N2O5
InChIKey:VLTIIVOWJQDNHG-ZETCQYMHSA-N
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Compound 8b
Molecular Weight:260.2869
Molecular Formula:C11H20N2O5
InChIKey:VLTIIVOWJQDNHG-SSDOTTSWSA-N
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