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Aerobic Amide Bond Formation with N-hydroxysuccinimide

Authors

  • Haoyi Yao,

    1. Department of Chemistry and School for Green Chemistry and Engineering, The University of Toledo, Toledo, OH 43606 (USA)
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  • Prof. Dr. Kana Yamamoto

    Corresponding author
    1. Department of Chemistry and School for Green Chemistry and Engineering, The University of Toledo, Toledo, OH 43606 (USA)
    • Department of Chemistry and School for Green Chemistry and Engineering, The University of Toledo, Toledo, OH 43606 (USA)

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Abstract

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Breathe easy: Molecular oxygen is one of the most abundant, atom-efficient, and economical oxidants. An aerobic oxidative amide formation from aldehydes and amines is reported. The method uses a catalytic amount of Co(OAc)2 and N-hydroxysuccinimide as reaction promoters. It is applicable to chiral substrates without loss of their optical purity.

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