The transformation of CH bonds into other chemical bonds is of great significance in synthetic chemistry. CH bond-activation processes provide a straightforward and atom-economic strategy for the construction of complex structures; as such, they have attracted widespread interest over the past decade. As a prevalent directing group in the field of CH activation, the amide group not only offers excellent regiodirecting ability, but is also a potential CN bond precursor. As a consequence, a variety of nitrogen-containing heterocycles have been obtained by using these reactions. This Focus Review addresses the recent research into the amide-directed tandem CC/CN bond-formation process through CH activation. The large body of research in this field over the past three years has established it as one of the most-important topics in organic chemistry.