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Amide-Directed Tandem C[BOND]C/C[BOND]N Bond Formation through C[BOND]H Activation

Authors

  • Dr. Chen Zhu,

    Corresponding author
    1. Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9038 (USA), Fax: (+1) 214-648-6455
    • Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9038 (USA), Fax: (+1) 214-648-6455

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  • Dr. Rui Wang,

    1. Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9038 (USA), Fax: (+1) 214-648-6455
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  • Prof. Dr. John R. Falck

    1. Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9038 (USA), Fax: (+1) 214-648-6455
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Abstract

The transformation of C[BOND]H bonds into other chemical bonds is of great significance in synthetic chemistry. C[BOND]H bond-activation processes provide a straightforward and atom-economic strategy for the construction of complex structures; as such, they have attracted widespread interest over the past decade. As a prevalent directing group in the field of C[BOND]H activation, the amide group not only offers excellent regiodirecting ability, but is also a potential C[BOND]N bond precursor. As a consequence, a variety of nitrogen-containing heterocycles have been obtained by using these reactions. This Focus Review addresses the recent research into the amide-directed tandem C[BOND]C/C[BOND]N bond-formation process through C[BOND]H activation. The large body of research in this field over the past three years has established it as one of the most-important topics in organic chemistry.

Abstract

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