Communication

Senegalensions A–C, Three Limonoids from Khaya senegalensis

  1. Dr. Chun-Mao Yuan1,2,†,
  2. Dr. Yu Zhang1,†,
  3. Dr. Gui-Hua Tang1,
  4. Dr. Shun-Lin Li1,
  5. Dr. Ying-Tong Di1,
  6. Li Hou1,
  7. Jie-Yun Cai1,
  8. Prof. Hui-Ming Hua2,*,
  9. Prof. Hong-Ping He1,*,
  10. Prof. Xiao-Jiang Hao1,*

Article first published online: 25 JUN 2012

DOI: 10.1002/asia.201200320

Issue

Chemistry – An Asian Journal

Chemistry – An Asian Journal

Volume 7, Issue 9, pages 2024–2027, September 2012

Additional Information

How to Cite

Yuan, C.-M., Zhang, Y., Tang, G.-H., Li, S.-L., Di, Y.-T., Hou, L., Cai, J.-Y., Hua, H.-M., He, H.-P. and Hao, X.-J. (2012), Senegalensions A–C, Three Limonoids from Khaya senegalensis. Chem. Asian J., 7: 2024–2027. doi: 10.1002/asia.201200320

Author Information

  1. 1

    State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Lanhei road 132, Heilongtan Kunming Yunnan 650201 (China), Fax: (+86) 871-5223070

  2. 2

    Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Wenhua road 103, Shenhe district Shenyang Liaoning 110016 (China), Fax: (+86) 2423986465

  1. †

    These authors have contributed equally to this work.

* Hui-Ming Hua, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Wenhua road 103, Shenhe district Shenyang Liaoning 110016 (China), Fax: (+86) 2423986465
Hong-Ping He, State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Lanhei road 132, Heilongtan Kunming Yunnan 650201 (China), Fax: (+86) 871-5223070
Xiao-Jiang Hao, State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Lanhei road 132, Heilongtan Kunming Yunnan 650201 (China), Fax: (+86) 871-5223070

  1. †

    These authors have contributed equally to this work.

Publication History

  1. Issue published online: 22 AUG 2012
  2. Article first published online: 25 JUN 2012
  3. Manuscript Received: 10 APR 2012

Funded by

  • NSFC. Grant Number: 30830114
  • Ministry of Science and Technology. Grant Numbers: 2009CB522300, 2009CB940900
  • Young Academic and Technical Leader Raising Foundation of Yunnan Province. Grant Number: 2010CI047

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Keywords:

  • biosynthesis;
  • computational chemistry;
  • limonoids;
  • natural products;
  • structure elucidation
Thumbnail image of graphical abstract

Hidden treasures: Senegalensions A (1) and B (2) with a unique C2–C4 linkage and senegalension C (3), possessing a rare spiro ring system with an unusual tricyclo[3.3.1.01, 10]nonane moiety, were isolated from the leaves and twigs of Khaya senegalensis. Their structures were elucidated by extensive spectroscopic analysis. The absolute configuration of 1 was determined by computational methods. A plausible biosynthetic pathway was proposed.

Featured Compounds

Compound 1
Molecular Weight:514.5211
Molecular Formula:C27H30O10
InChIKey:HHKXOKUGOZKYPR-ZLUJZDLSSA-N
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Compound 2
Molecular Weight:556.5578
Molecular Formula:C29H32O11
InChIKey:PKKJFJBYANOCFN-UOLJPPLWSA-N
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Compound 3
Molecular Weight:514.5211
Molecular Formula:C27H30O10
InChIKey:JHMZULGCJXJTEF-CYJMCVCUSA-N
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View Full Article with Supporting Information (HTML) Get PDF (450K)