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Mono-PEGylated Zinc(II) Phthalocyanines: Preparation, Nanoparticle Formation, and In Vitro Photodynamic Activity

Authors

  • Dr. Baozhong Zhao,

    1. Department of Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong (China), Fax: (+852) 2603-5057
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    • These authors contributed equally to this work.

  • Prof. Wubiao Duan,

    1. Department of Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong (China), Fax: (+852) 2603-5057
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    • These authors contributed equally to this work.

  • Prof. Pui-Chi Lo,

    1. Department of Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong (China), Fax: (+852) 2603-5057
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  • Lei Duan,

    1. Department of Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong (China), Fax: (+852) 2603-5057
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  • Prof. Chi Wu,

    1. Department of Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong (China), Fax: (+852) 2603-5057
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  • Prof. Dennis K. P. Ng

    Corresponding author
    1. Department of Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong (China), Fax: (+852) 2603-5057
    • Department of Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong (China), Fax: (+852) 2603-5057

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Abstract

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PEGged! A series of mono-PEGylated zinc(II) phthalocyanines for photodynamic therapy with singlet oxygen have been prepared and formulated in aqueous media with different methods. The system based on silica nanoparticles exhibits remarkably high stability and in vitro photocytotoxicity.

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