Copper-Catalyzed Synthesis of α-Hydroxy Phosphonates from H-Phosphonates and Alcohols or Ethers

Authors

  • Zengxiang Zhao,

    1. Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, 422N, Siming South Road, Xiamen 361005 (China), Fax: (+86) 592-2185780
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  • Wanhua Xue,

    1. Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, 422N, Siming South Road, Xiamen 361005 (China), Fax: (+86) 592-2185780
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  • Yuxing Gao,

    1. Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, 422N, Siming South Road, Xiamen 361005 (China), Fax: (+86) 592-2185780
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  • Guo Tang,

    Corresponding author
    1. Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, 422N, Siming South Road, Xiamen 361005 (China), Fax: (+86) 592-2185780
    • Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, 422N, Siming South Road, Xiamen 361005 (China), Fax: (+86) 592-2185780

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  • Yufen Zhao

    1. Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, 422N, Siming South Road, Xiamen 361005 (China), Fax: (+86) 592-2185780
    2. Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Haidian, Beijing 100084 (P. R. China)
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Abstract

original image

Easy PC: α-Hydroxy phosphonates were synthesized by copper/tert-butyl hydroperoxide (TBHP)-catalyzed oxidative addition reactions of H-phosphonates with alcohols or ethers. Diverse α-hydroxy phosphonates were obtained from substituted benzyl alcohols or alkyl alcohols and alkyl ethers in moderate to good yields.

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