Synthesis of Functionalized Aryl Fluorides Using Organolithium Reagents in Flow Microreactors

Authors

  • Dr. Aiichiro Nagaki,

    1. Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510 (Japan), Fax: (+81) 75-383-2727
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  • Yuki Uesugi,

    1. Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510 (Japan), Fax: (+81) 75-383-2727
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  • Heejin Kim,

    1. Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510 (Japan), Fax: (+81) 75-383-2727
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  • Prof. Dr. Jun-ichi Yoshida

    Corresponding author
    1. Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510 (Japan), Fax: (+81) 75-383-2727
    • Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510 (Japan), Fax: (+81) 75-383-2727

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Abstract

original image

Flow on: Flow microreactors enable the generation of aryl lithium compounds and subsequent electrophilic fluorination with NFSI and N-fluorosultam. The reaction can be successfully accomplished to synthesize various aryl fluorides involving an electron-withdrawing, an electron-donating, and a sterically hindered functional group in good yields.

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