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Keywords:

  • fluorination;
  • lithiation;
  • microreactors;
  • synthetic methods
Thumbnail image of graphical abstract

Flow on: Flow microreactors enable the generation of aryl lithium compounds and subsequent electrophilic fluorination with NFSI and N-fluorosultam. The reaction can be successfully accomplished to synthesize various aryl fluorides involving an electron-withdrawing, an electron-donating, and a sterically hindered functional group in good yields.