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New Entry to Polycyclic Fused Indoles via Gold(I)-catalyzed Cascade Reaction

Authors

  • Dr. Michel Chiarucci,

    1. Department of Chemistry “G. Ciamician”, Alma Mater Studiorum—University of Bologna via Selmi 2, 40138 Bologna (Italy), Fax: (+39) 051-2099456
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  • Elia Matteucci,

    1. Department of Chemistry “G. Ciamician”, Alma Mater Studiorum—University of Bologna via Selmi 2, 40138 Bologna (Italy), Fax: (+39) 051-2099456
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  • Gianpiero Cera,

    1. Department of Chemistry “G. Ciamician”, Alma Mater Studiorum—University of Bologna via Selmi 2, 40138 Bologna (Italy), Fax: (+39) 051-2099456
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  • Prof. Giancarlo Fabrizi,

    1. Dipartimento di Chimica e Tecnologia del Farmaco, Sapienza, Università di Roma, P.le A. Moro, 5, Rome (Italy)
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  • Prof. Marco Bandini

    Corresponding author
    1. Department of Chemistry “G. Ciamician”, Alma Mater Studiorum—University of Bologna via Selmi 2, 40138 Bologna (Italy), Fax: (+39) 051-2099456
    • Department of Chemistry “G. Ciamician”, Alma Mater Studiorum—University of Bologna via Selmi 2, 40138 Bologna (Italy), Fax: (+39) 051-2099456

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Abstract

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The gold standard: A gold-catalyzed cascade reaction sequence for the preparation of polycyclic fused indole cores exploits the ready availability and chemical flexibility of propargylic alcohols. The desired tri- or tetracyclic compounds are obtained in good yields with water as the only stoichiometric by-product.

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