Cover Picture: Selective Detection of Multicarboxylate Anions based on “Turn on” Electron Transfer by Self-Assembled Molecular Rectangles (Chem. Asian J. 11/2012)



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Catalytic cross-dehydrogenative coupling (CDC) reactions have become useful in C[BOND]H bond activation. In their Full Paper on page 2599 ff., Shogo Hashizume, Kounosuke Oisaki, and Motomu Kanai demonstrate that the copper-catalyzed migratory oxidative coupling reaction between nitrones and ethers/amines exhibits a high tolerance of functional groups. The reaction proceeds at room temperature in the near-neutral pH range, even under aqueous conditions. These characteristics are favorable for future extension to convergent and protecting group-free catalytic construction of carbon skeletons, as well as for the chemical labeling of biologically relevant molecules.