Get access
Advertisement

Catalytic Asymmetric Synthesis of Spirooxindoles via Addition of Isothiocyanato Oxindoles to Aldehydes Under Dinuclear Nickel Schiff Base Catalysis

Authors

  • Shota Kato,

    1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan), Fax: (+81) 3-5684-5206
    Search for more papers by this author
  • Prof. Dr. Motomu Kanai,

    Corresponding author
    1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan), Fax: (+81) 3-5684-5206
    • Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan), Fax: (+81) 3-5684-5206

    Search for more papers by this author
  • Dr. Shigeki Matsunaga

    Corresponding author
    1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan), Fax: (+81) 3-5684-5206
    2. ACT-C, Japan Science and Technology Agency, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan)
    • Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan), Fax: (+81) 3-5684-5206

    Search for more papers by this author

Abstract

original image

One-step approach: A homodinuclear nickel Schiff base catalyst was utilized for the title reaction, thus providing easy access to spirocyclic oxindole compounds in one step. High enantioselectivity as well as high catalyst turnover number (TON, up to 850) were achieved at ambient temperature.

Get access to the full text of this article

Ancillary